A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension
Conclusion:
In patients with hypertension, a 4-week treatment with firibastat, tended to decrease daytime SBP relative to placebo. Firibastat did not modify the activity of the systemic renin–angiotensin system These results have justified designing a larger, powered trial of longer duration to fully assess its safety and effectiveness.
Clinical trial registration:
http://www.clinicaltrials.gov. NCT02322450.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research
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