Reliability of Histopathology for the Early Recognition of Fibrosis in Traction Alopecia: Correlation with Clinical Severity

In this study, 45 patients were assessed using the marginal TA severity scoring system, and their biopsies (both longitudinal and transverse sections) were systematically assessed by three dermatopathologists, the aim being to correlate histopathological findings with clinical staging. Intraclass correlation coefficients were used to determine the level of agreement between the assessors. We found poor agreement of the identification and grading of perifollicular and interfollicular fibrosis (0.55 [0.23 –0.75] and 0.01 [2.20–0.41], respectively), and no correlation could be drawn with the clinical severity score. Better methods of diagnosis are needed for grading and for recognition of early fibrosis in TA.Dermatopathology 2019;6:170 –181
Source: Dermatopathology - Category: Pathology Source Type: research

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Conclusion: This study provides novel methods for the construction of stem cell microenvironments and experimental models of HF regeneration for the treatment of hair loss.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
(University of Cologne) An international research team has shown in mice that Rictor, a protein that helps to regulate the growth, energy, and oxygen consumption of cells, plays a key role in the cellular metabolism and longevity of hair follicle stem cells / publication in 'Cell Metabolism'
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusions: The progressive conjunctivalization, spontaneous epithelial defects, and anterior segment optical coherence tomography features are highly suggestive of limbal stem cell dysfunction in IFAP syndrome. Optimizing the ocular surface is of importance in the management of children with this rare disease.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
They go by different names: goosebumps, goose pimples, goose flesh, and my personal favorite, goose bumples. The medical term is cutis anserine (cutis means skin and anser means goose). I guess the similarity in texture is just too close to goose skin to ignore. Other medical terms for goosebumps are horripilation, piloerection, or the pilomotor reflex. Each of these terms describes a temporary change in the skin from smooth to bumpy, most commonly developing after exposure to cold. Many people associate goosebumps with fear, or perhaps more accurately, with horror. Perhaps that’s why a popular series of children&rsq...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Skin and Hair Care Source Type: blogs
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the tr...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Researchers here analyze amounts and types of glycans in stem cells isolated from the skin of old and young mice. The differences observed might serve as a biomarker of aging, but also may be a contributing proximate cause of the age-related decline in skin stem cell function. As is usually the case, connecting downstream changes of this nature to the deeper causes of aging is a project yet to make any meaningful progress. It is also unclear as to whether glycan profile changes are a sizable cause of dysfunction versus all of the other possible proximate causes of stem cell functional decline. Aging in the epiderm...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
In conclusion, early treatment and an optimal dose of mesenchymal stem cells can effectively suppress the murine SLE model. PMID: 32580680 [PubMed - in process]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
The hairless (Hr) gene plays an essential role in hair follicle development and skin homeostasis. Both humans and mice lacking hairless activity suffer from complete hair loss and abnormal epidermal proliferation and differentiation, although the mechanisms underlying such developmental defects remain largely unknown. We recently demonstrated that Hr encodes a histone demethylase and acts as an epigenetic regulator of the expression of its target genes. Gene expression profiling studies identified pro-inflammatory IL-1 family cytokines, including IL-36 and IL-1 β, among the major targets of Hr.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
Hair transplantation for the management of androgenetic alopecia is often limited by the number of donor HFs available for transplantation. Therefore, HF neogenesis technologies that enlarge the number of donor HFs are needed. Here, we assessed the potential of human primary adult hair matrix keratinocytes (HMx), i.e. the cells interacting with dermal papilla fibroblasts (DPs) in vivo, in generating HF organoids when co-cultured with DP spheroids in vitro and in human skin organ culture, compared to primary human adult epidermal keratinocytes (NHEK).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
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