Genomic and transcriptomic comparison of post-radiation versus sporadic sarcomas

Modern Pathology, Published online: 26 June 2019; doi:10.1038/s41379-019-0300-2Genomic and transcriptomic comparison of post-radiation versus sporadic sarcomas
Source: Modern Pathology - Category: Pathology Authors: Source Type: research

Related Links:

Publication date: Available online 17 August 2019Source: Urology Case ReportsAuthor(s): Mehdi Kardoust Parizi, Solmaz Ohadian Moghadam, Seyed Ali MomeniAbstractGenitourinary tract liposarcoma is considered as the second most commonly reported type of sarcomas. Renal liposarcoma with tumor invasion to inferior vena cava (IVC) is distinctly rare. This tumor has a relatively indolent clinical course with risk of local recurrences (20%-85% rate) after surgery. Angiomyolipomas (AML) are the most important differential diagnosis because both are large fat-containing lesions. Herein, a patient with upper pole kidney liposarcoma w...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionIntracranial SS were more frequently observed in the supratentorial region and in young patients without sex predilection. We recommend adjuvant radiation regardless of the extent of resection. More patients and longer follow-up periods were needed to further elucidate the biological features of intracranial SS.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Contributors : Julian Musa ; Marie-Ming Aynaud ; Sandrine Grosset ête-Lalami ; Olivier Mirabeau ; Olivier Delattre ; Thomas G GrünewaldSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDeciphering principles of inter-individual tumor heterogeneity is essential for refinement of personalized anti-cancer therapy. Unlike cancers of adulthood, pediatric malignancies including Ewing sarcoma feature a striking paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here we demonstrate in the Ew...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Julian Musa ; Marie-Ming Aynaud ; Sandrine Grosset ête-Lalami ; Olivier Mirabeau ; Olivier Delattre ; Thomas G GrünewaldSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDeciphering principles of inter-individual tumor heterogeneity is essential for refinement of personalized anti-cancer therapy. Unlike cancers of adulthood, pediatric malignancies including Ewing sarcoma feature a striking paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here we demonstrate in the Ewing sarcoma mo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Shiga A, Katoh Y, Ito T, Ohnuma-Koyama A, Takahashi N, Okazaki Y, Harada T Abstract An extraskeletal osteosarcoma was detected in the auricle of a 110-week-old female Wistar Hannover rat. Grossly, the tumor, measuring 15 mm in size, was observed in the subcutis as a solid and hard mass. Histologically, the majority of the mass comprised mature, compact bone. It was surrounded by neoplastic cells showing a variety of histologies, such as sarcoma, not otherwise specified, and myxosarcoma away from the bone-forming region. However, these different histological regions were considered to be components of a sin...
Source: Journal of Toxicologic Pathology - Category: Toxicology Tags: J Toxicol Pathol Source Type: research
In conclusion misdiagnosis of an isolated painless axillary mass as a lipoma, as occurred in our patient, allowed this malignancy to reach considerable size. The progressive neurology provided the red flag for urgent surgical intervention.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
AbstractPurpose of ReviewThis review presents a selection of regulatory molecules of tumor microenvironmental properties and metastasis. Signaling pathways controlling mesenchymal biology in bone and soft-tissue sarcomas found in children and adolescents are prioritized.Recent FindingsThe tumor microenvironment of pediatric tumors is still relatively unexplored. Highlighted findings are mainly on deregulated genes associated with cell adhesion, migration, and tumor cell dissemination. How these processes are involved in a mesenchymal phenotype and metastasis is further discussed in relation to the epithelial to mesenchymal...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Authors: Duran-Moreno J, Kontogeorgakos V, Koumarianou A Abstract Soft tissue sarcomas (STS) are rare tumors; they do not even equate to 1% of all malignant tumor cases. One-fifth of all STS occur in the upper extremities, where epithelioid sarcoma, synovial sarcoma, clear cell sarcoma and malignant fibrohistiocytoma are the most frequent subtypes. Surgical resection is the cornerstone of treatment. However, accomplishment of optimal oncological and functional results of STS of the upper extremities may represent a challenge for hand surgeons, due to the complex anatomy. In several cases, preoperative therapies are...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Condition:   Soft Tissue Sarcoma Interventions:   Drug: Doxil;   Drug: Doxorubicin Sponsor:   Fox Chase Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Pathology | Sarcomas