Podcast: Antioxidants for male subfertility

As well as strategies that are focused mainly on the woman, interventions to help couples to become pregnant include some to directly help men who are subfertile and those targeting men where the couple has unexplained subfertility. One of the Cochrane Reviews with this focus on men looks at giving them oral supplementation with antioxidants, and new evidence was added to this in March 2019. We asked Rebecca Mackenzie ‐Proctor from the Auckland City Hospital in New Zealand to bring us to up-to-date..Many cases of male subfertility are thought to be due to the damaging effects of oxidative stress on sperm, with some estimates putting this as high as four in five men. Oxidative stress occurs when cells break down and release reactive oxygen species chemicals. This damages the sperm and its ability to fertilise an egg. One way that has been suggested to overcome it in men with low natural levels of antioxidants, is for them take these as supplements, and our review suggests that this might be helpful. This is similar to our 2017 Cochrane Review studying the effects of antioxidant supplementation for women, which also showed a positive association with increased rates of live birth or clinical pregnancy.The previous version of this review of antioxidants for men was published in 2014 and this update has allowed us to add in a further 13 studies. This means that we are now evaluating 61 randomised trials, with more than 6000 couples attending fertility clinics. We included trial...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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FRIDAY, Oct. 9, 2020 -- Pregnancy complications, including preeclampsia and miscarriage, may be linked to an increased risk of heart disease later in life, a new study suggests. For the study, the researchers analyzed 32 reviews that assessed women...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
(Imperial College London) One in 12 partners experience post-traumatic stress after miscarriage, suggests a new study. The research, led by Imperial College London, surveyed over 100 couples who had experienced early stage pregnancy loss (miscarriage or ectopic pregnancy before 12 weeks).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionThe prevalence of gestational PHPT was 2.1% in this largest Indian PHPT cohort, which is higher than that reported from the West (
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Abstract Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the increased macroautophagy/autophagy of decidual stromal cells (DSCs) during decidualization, facilitates the adhesion and retention of dNK cells during normal pregnancy. Mechanistically, this process is mediated through activation of the MITF-TNFRSF14/HVEM signaling, and further upregulation of mul...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
CONCLUSIONS: Partners experience far lower levels of post-traumatic stress, anxiety and depression than women after early pregnancy loss. This article is protected by copyright. All rights reserved. PMID: 33032364 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
The disease caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2) was named Coronavirus Disease 19 (COVID-19) and classified as a global public health emergency. The evidence related to the impact of COVID-19 on pregnancy are limited to the second and the third trimester of pregnancy, while data on the first trimester are scant. Many viral infections can be harmful to the fetus during the first trimester of pregnancy, and whether SARS-CoV-2 is one of them is still unknown.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Original Research: Obstetrics Source Type: research
This study seeks to provide an up-to-date systematic review and meta-analysis of the relationship between these three forms of pregnancy loss and the subsequent development of CVD.MethodsThis systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analysis checklist (PRISMA) and the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) Checklist. A systematic search will be undertaken using publications identified in MEDLINE (PubMed), Scopus, Web of Knowledge, the CINAHL Nursing Database, and the Cochrane Library. The eligibility of each publication will be determined by predefin...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
ConclusionsIn this study, we found that it is feasible to set up and achieve fidelity of a model of midwifery continuity of care linked with specialist obstetric care for women at increased risk of PTB in an inner-city maternity service in London (UK), but there is no impact on most outcomes for this population group. Larger appropriately powered trials are needed, including in other settings, to evaluate the impact of relational continuity and hypothesised mechanisms of effect based on increased trust and engagement, improved care coordination, and earlier referral on disadvantaged communities, including women with comple...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
CONCLUSION: This study found that the recording of pre-pregnancy advice and contraception in women of childbearing age who were prescribed an ACE inhibitor or an ARB was suboptimal; this may place women and their babies at risk of exposure to teratogens during pregnancy. The findings indicate that there is a need for improved safety strategies based in primary care. PMID: 33020169 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - Category: Primary Care Authors: Tags: Br J Gen Pract Source Type: research
CONCLUSIONS: By promoting the expression of related proteins and regulating the functions of HTR8/SVneo cells, CsA can promote vascular recasting and placental function, which may affect the pathogenesis of PE. PMID: 33032826 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
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