Spirochetal Diseases and Seventh Nerve Palsy: A Clinical Dilemma Between Syphilis and Lyme Disease

We describe a 20-year-old woman with left seventh nerve palsy secondary to latent syphilis of unknown duration, with complete recovery after penicillin G benzathine. In addition to reactive rapid plasma reagin and positive T. pallidum particle agglutination testing, Lyme enzyme-linked immunosorbent assay was equivocal, and Lyme Western blot was positive for immunoglobulin M. In syphilis, Lyme enzyme-linked immunosorbent assay may be falsely positive, but Western blot is known to remain negative. Similarly, in LD, fluorescent treponemal antibody absorption testing may be falsely positive, but rapid plasma reagin remains nonreactive. Careful interpretation of these serologic tests is of utmost importance in differentiating between the 2, especially in areas with low prevalence of LD.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research

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ConclusionsOur results show that Tp0136 facilitates differential level of binding to cell lines representing various host tissues, which highlights the importance of this protein in colonization of human organs byT.pallidum and resulting syphilis pathogenesis.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
CONCLUSIONS: Immunization with native antigens might not be sufficient to obtain complete protection to infection. Nonetheless we showed that non-infectious B. burgdorferi can be an effective carrier to deliver and elicit a specific host response to T. pallidum antigens to assess the efficacy of syphilis vaccine candidates. PMID: 30797635 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Authors: Eldin C, Jaulhac B, Mediannikov O, Arzouni JP, Raoult D Abstract Bacteria of the Borrelia burgdorferi sensu lato complex, responsible for Lyme disease, are members of the spirochetes phylum. Diagnostic difficulties of Lyme disease are partly due to the characteristics of spirochetes as their culture is tedious or even impossible for some of them. We performed a literature review to assess the value of the various diagnostic tests of spirochetes infections of medical interest such as Lyme borreliosis, relapsing fever borreliae, syphilis, and leptospirosis. We were able to draw similarities between these fou...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
The study compares diagnostic parameters of different commercial serological kits based on three different antigen types and correlates test results with the status of the patient's Borrelia infection. In total, 8 IgM and 8 IgG kits were tested, as follows: enzyme-linked immunosorbent assay (ELISA) (Euroimmun) based on whole-cell antigen, 3 species-specific enzyme immunoassays (EIAs) (TestLine), Liaison chemiluminescence (DiaSorin), ELISA-Viditest (Vidia), EIA, and Blot-Line (TestLine) using recombinant antigens. All tests were performed on a panel of 90 samples from patients with clinically characterized borreliosis (53 w...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research
Conclusions:By education and restricted use initiatives, inappropriate CSF Lyme PCR testing for diagnosing neuroborreliosis was significantly affected. This initiative led to reduced healthcare costs for the institution and patient while improving evidence based medical practices.Disclosure: Dr. Vanino has nothing to disclose. Dr. Baldwin has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Infectious Disease: HIV, Syphilis, Borrelia, TB, Cysticercosis, and Other Infections Source Type: research
Conclusions:With this review we intend to demonstrate the wide range of neurological symptoms that LN can cause, and enhance that epidemiological context and clinical suspicion are important factors to the diagnosis.Disclosure: Dr. Espírito Santo has nothing to disclose. Dr. Almendra has nothing to disclose. Dr. Mendes has nothing to disclose. Dr. Veiga has nothing to disclose. Dr. Costa has nothing to disclose. Dr. Velon has nothing to disclose. Dr. Guimarães has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Conclusions:Although mechanical causes are high in the differential diagnosis of cervical radiculopathy, Lyme disease is well-known to have symptoms of radiculitis and should be considered in the assessment of cervical pain. A typical early syndrome due to neuroborreliosis has been characterized as a triad of the symptoms mentioned above including radicular pain, cranial or peripheral paresis, and lymphocytic meningitis and is called "Bannwarths syndrome" (Bannwarth, 1941).Disclosure: Dr. Hannoun has nothing to disclose. Dr. Gudin has received personal compensation for activities with Purdue, Endo, Astra Zeneca, ...
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
This article is protected by copyright. All rights reserved. Swimming with sugar: We demonstrate that the flagellar filament proteins of oral bacterium Treponema denticola are modified with a novel glycan (a C7‐acylated pseudaminic acid derivative, m/z 451.2) and that such a modification is essential for flagellar assembly and motility.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research
This morning, I awoke to find that I had been copied on dozens of Twitter message exchanges among several people who were discussing the pathology of Borrelia burgdorferi, the bacterium that causes Lyme disease, among human beings and mice. My first thought was "Seriously?! It's too early for this!" My second thought was "well, David, your Twitter sure has evolved from your pre-Lyme days when you used it mostly to promote vapid celebrity interviews." As I began my morning caffeine ritual and read through each of the messages, I gained a new appreciation for some of the real complexities of "in...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
"Who knew there would be so much interest in a biomechanics paper??!!" Those are the words--and the multiple exclamation points--of Tara Moriarty, proprietor of the Moriarty Lab, an infectious diseases research lab that studies primarily Borrelia burgdorferi (Bb) the bacterium that causes Lyme disease. Moriarty is the principal investigator of a new academic paper from the University of Toronto that details the mechanism by which Bb "crawl" through the body. Scientific American is among the many mainstream outlets that discussed the findings, which may represent a major step in making t...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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