Study questions success of health intervention currently used in developing countries

(Carnegie Mellon University) In the early 20th century, researchers in Massachusetts studied the first community-based health intervention in the world, the Framingham Health and Tuberculosis Demonstration, deeming it highly successful in controlling tuberculosis (TB) and reducing mortality. Now a new study has concluded that the effort was not as successful as initially thought, and suggests that the intervention cannot be cited as evidence for the success of health policies in the era before antibiotics became available.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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In this study, we compared the immunogenicity and protective efficacy of CMFO subunit vaccines against primary progressive TB in two different adjuvant systems: the MTO oil-in-water (O/W) emulsion composed of monophosphoryl lipid A (MPL), trehalose-6,60-dibehenate (TDB), and oil in water emulsion MF59 and the DMT liposome containing dimethyldioctadecylammonium bromide (DDA), monophosphoryl lipid A (MPL), and trehalose-6,60-dibehenate (TDB). Our results demonstrated that the DMT-adjuvanted CMFO could confer more significant protection against M. tuberculosis infection than the CMFO/MTO did in mice. In particular, the adjuva...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 22 September 2020Source: IDCasesAuthor(s): Don Bambino Geno Tai, Christopher S Graffeo, Amy Kotsenas, Fredric B Meyer, Abinash Virk
Source: IDCases - Category: Infectious Diseases Source Type: research
Authors: Yong LN, Ahmedy F, Yin KN, Engkasan JP Abstract Spinal tuberculosis often leads to neurological deficit and subsequent deterioration in functional outcomes. This review assesses the recent evidence on functional outcomes in spinal tuberculosis, highlighting functional recovery, assessment tools for functional measures, and associative factors for functional recovery. Using PubMed, a literature search was done using the terms "spinal tuberculosis," "tuberculous spondylitis," "tuberculous spondylodiscitis," and "functional outcome" for original articles published betwe...
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, although it did not improve BCG efficacy, denoting the need to search for improved tuberculosis vaccines. In this work, we investigated the effect of IL-12 DNA -as an adjuvant- on an Ag85A DNA prime/MVA85A boost vaccination regimen. We evaluated the immune response profile elicited in mice and the protection conferred against intratracheal Mtb H37Rv challenge. We observed that the immunization scheme inclu...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02062A, PaperManisha Lobo, Rajdeep Ray, Gautham G. Shenoy Bedaquiline is a diarylquinoline antimycobacterial drug prescribed for the treatment of Multidrug-Resistant Tuberculosis (MDR-TB). It targets the energy metabolism of the bacteria by inhibiting the proton pump of mycobacterial ATP... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Bacillus Calmette-Guérin (BCG) vaccination induces variable protection against pulmonary tuberculosis (TB), and a more effective TB vaccine is needed. The potential for BCG to provide protection against heterologous infections, by induction of innate immune memory, is increasingly recognized. These nonspecific responses may substantially benefit public health, but are also variable. In this issue of the JCI, Koeken and de Bree et al. report that BCG reduces circulating inflammatory markers in males but not in females, while de Bree and Mouritis et al. describe how diurnal rhythms affect the degree of BCG-induced inn...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSIONS BCG vaccination in the morning induces stronger trained immunity and adaptive responses compared with evening vaccination. Future studies should take vaccine administration time into account when studying specific and nonspecific effects of vaccines; early morning should be the preferred moment of BCG administration.FUNDING The Netherlands Organization for Scientific Research, the European Research Council, and the Danish National Research Foundation.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Secondary organizing pneumonia (SOP) is difficult to distinguish from cryptogenic organizing pneumonia (COP) considering various clinical situations. SOP caused by Mycobacterium tuberculosis is rare; indeed, it h...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
ConclusionIt is feasible to conduct signal detection analyses for DDIs within relatively small SRS databases. However, the observed potential SDR for the respective DDI should be investigated further as the method is only a hypothesis-generation analysis.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
In conclusion, we demonstrated that the workflow and sequencing data obtained from Deeplex on MinION are comparable to those for the MiniSeq, despite the higher raw error rates on MinION, with the added advantage of MinION’s portability, versatility, and low capital costs. Targeted NGS on MinION is a promising DST solution for rapidly providing clinically relevant data to manage complex DR-TB cases.
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Mycobacteriology and Aerobic Actinomycetes Source Type: research
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