GSE132500 Transcriptome studies of marine natural products 4a and 4d on non-small cell lung cancer A549 cells

Contributors : Heng Xu ; Hao Zhang ; Cheng Luo ; Xu-Wen LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTwo novel polyketides, ocellatusones A and B (1 and 2), characterized by either an uncommon oxatricyclo[4.2.1.02,4]nonane skeleton (1) or a mesitylene connected dimethylfuran-3(2H)-one nucleus (2), were isolated in racemic forms from the South China Sea sacoglossan Placobranchus ocellatus, together with seven uncommon polypropionates (3, 4a,4d, 5, and 6). Compounds 1 and 2 were further separated by chiral HPLC to their corresponding enantiomers ( ±)-1 and (±)-2, respectively. The structures, including absolute configurations, of the new compounds, were unambiguously determined by extensive spectroscopic analysis, quantum chemical computation, and/or X-ray diffraction analysis. The new compounds (+)-1, 4a, 4b, 4d exhibited interesting dose dependent cytotoxic effect on human cancer cell lines, including non-small cell lung cancer and acute promyelocytic leukemia, with IC50 values ranging from 6.1 μM to 28.8 μM. A plausible bio-photosynthetic pathway of these isolates was proposed.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research