Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease

ConclusionsAortic stiffness and interstitial myocardial fibrosis are interrelated; this association is accelerated in the presence of CKD, but independent of LGE. Our findings reiterate the significant contribution of CKD-related factors to the pathophysiology of cardiovascular remodeling.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research

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ConclusionsAmong individuals with CKD, single measurements of cFGF-23 improve prediction of risks for all-cause mortality and HF admission but not CV mortality, ESRD, or atherosclerotic events. Future studies should evaluate the predictive utility of repeated cFGF-23 testing.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Introduction: Calciphylaxis is characterized by calcification of the small and medium caliber vessels of the dermis and subcutaneous cellular tissue. It is more common in patients with chronic kidney disease (CKD) on dialysis, but is also described in patients with other risk factors such as secondary hyperparathyroidism, heart failure (HF), diabetes mellitus type 2 (DM-2), hypercoagulable states and drugs such as warfarin. The mortality rate is high, with sepsis being the most frequent complication.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
AbstractBackgroundFunctional limitations may be more common in middle-aged adults than previously recognized. However, there are few published data on the prevalence of activity limitations, and their association with multimorbidity, among adults 50 to 64  years old.ObjectiveTo describe the prevalence of activity limitations and the association with multimorbidity in middle-aged adults.DesignCross-sectional analysis of US population-based National Health and Nutrition Examination Survey (NHANES) 2011 –2016.ParticipantsThe total number of community-dwelling NHANES participants aged 50 –64 years old is ...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Authors: Sun HJ Abstract Arterial hypertension remains to be a serious problem with considerable morbidity and mortality worldwide in the present age. Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial infarction, renal failure, and heart failure. Hypertensive nephropathy is the second leading cause of death in chronic kidney disease (CKD) around the world. Long-time hypertension loading results in renal interstitial fibrosis, which is associated with aberrant activation of renal fibroblasts and excessive generation of extracellular matrix (ECM) proteins. Increasing evidence ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
A 57-year-old man with a history of coronary artery disease, diastolic heart failure, obstructive sleep apnea, chronic kidney disease, morbid obesity, 60 pack-year smoking history, and gastric bypass (performed 20 years ago) presented to an outside institution with severe chest pain, sepsis, and pneumopericardium. He had no other history of abdominal or thoracic surgery. He was readmitted for heart failure exacerbation and was subsequently transferred to our institution for a higher level of care and possible surgical management.
Source: Surgery - Category: Surgery Authors: Source Type: research
AbstractBackgroundA higher heart rate is one of the risk factors for heart failure and cardiovascular disease. Activation of the intrarenal renin –angiotensin system (RAS) plays an important role in the development of hypertension and renal damage. However, the association between heart rate and intrarenal RAS activation is unclear.MethodsWe investigated the relationship between heart rate and urinary angiotensinogen (U-AGT) excretion, a surrogate marker for intrarenal RAS activity, in ten subjects without chronic kidney disease (CKD) and 72 CKD patients who were not taking medications that influence heart rate and R...
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Abstract Background and objectives: Obstructive sleep apnea syndrome (OSAS) and heart failure (HF) are increasing in prevalence with a greater impact on the health system. The aim of this study was to assess the particularities of patients with OSAS and HF, focusing on the new class of HF with mid-range ejection fraction (HFmrEF, EF = 40%-49%), and comparing it with reduced EF (HFrEF, EF
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Over the past several months, you may have heard that the FDA has recalled certain lots of angiotensin II receptor blocker (ARB) medications due to the presence of impurities. These contaminants — nitrosamine impurities — may occur as a byproduct of the manufacturing process. They include N-Nitrosodiethylamine (NDEA) and N-Nitrosodimethylamine (NDMA), which can potentially cause cancer. These substances are found in the environment as well in meats, dairy products, and water, but their presence in medications is not acceptable. Therefore, the FDA sets acceptable safety limits on the presence of these impurities...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Hypertension and Stroke Source Type: blogs
ConclusionsThe presence of significant DD identifies patients with LVEF>35% following MI who are at a higher risk of all-cause mortality, and who may benefit from further risk stratification and treatment.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Conclusion: In conclusion, liver cirrhosis is the major cause of ascites in Gondar, Ethiopia, while chronic viral hepatitis infections (hepatitis B (HBV) and C (HCV) viruses) are the main causes of liver cirrhosis. The other major causes included heart failure, tuberculosis, and hepatosplenic schistosomiasis. It is wise to consider and give priority to these diseases whenever one is evaluating a patient with ascites. PMID: 31360695 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
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