Cancers, Vol. 11, Pages 896: Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Na ïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12

Cancers, Vol. 11, Pages 896: Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12 Cancers doi: 10.3390/cancers11070896 Authors: Autore Strati Innocenti Corrente Trentin Cortelezzi Visco Coscia Cuneo Gozzetti Mauro Frustaci Gentile Morabito Molica Falcucci D’Arena Murru Vincelli Efremov Ferretti Rigolin Vitale Tisi Reda Visentin Sica Foà Ferrajoli Laurenti Chronic Lymphocytic Leukemia (CLL) patients with +12 have been reported to have specific clinical and biologic features. We performed an analysis of the association between demographic; clinical; laboratory; biologic features and outcome in CLL patients with +12 to identify parameters predictive of disease progression; time to treatment; and survival. The study included 487 treatment-naive CLL patients with +12 from 15 academic centers; diagnosed between January 2000 and July 2016; and 816 treatment-naïve patients with absence of Fluorescence In Situ Hybridization (FISH) abnormalities. A cohort of 250 patients with +12 CLL followed at a single US institution was used for external validation. In patients with +12; parameters associated with worse prognosis in the multivariate model were high Lactate DeHydrogenase (LDH) and β-2-microglobulin and unmutated immunoglobulin heavy-chain variable region gene (IGHV). CLL pa...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research