Effects of Cocarboxylase in Amikacin-Induced Ototoxicity in Immature Animals

Possible otoprotective properties of cocarboxylase were studied on the model of amikacin-induced ototoxicity in immature rabbits. Auditory function was evaluated by the short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) tests. Administration of cocarboxylase after modeling of amikacin-induced ototoxicity resulted in a decrease in the ABR peak I threshold and prevented damage to the outer hair cells.

Source: Bulletin of Experimental Biology and Medicine - June 25, 2019 Category: Biology Source Type: research