Clinical translation of FLASH radiotherapy: Why and how?

Radiation therapy (RT) is a major actor in cancer management, with more than half of all cancer patients treated with RT, mostly given with curative potential. RT generally exploits the empirical observation that normal tissues can recover from the harmful effects of ionizing radiation to a higher extent than tumors. This differential effect can be exacerbated by two factors that can independently increase the normal tissue tolerance. The first factor is the fractionation of the total dose with a good protection of normal tissues at 2  Gy per fraction and even more pronounced below 2 Gy/fraction [1].

Source: Radiotherapy and Oncology - June 24, 2019 Category: Radiology Authors: Jean Bourhis, Pierre Montay-Gruel, Patrik Gon çalves Jorge, Claude Bailat, Benoît Petit, Jonathan Ollivier, Wendy Jeanneret-Sozzi, Mahmut Ozsahin, François Bochud, Raphaël Moeckli, Jean-François Germond, Marie-Catherine Vozenin Tags: Original Article Source Type: research