Glyburide, a NLRP3 inhibitor, decreases inflammatory response and is a candidate to reduce pathology in Leishmania braziliensis infection

Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by an exaggerated inflammatory response that leads to parasite control, but is also the cause of tissue damage and ulcer formation (Carvalho et al., 2012). The NLRP3 Inflammasome is an intracellular protein complex which is activated by pathogen associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), promoting activation of caspase 1 and release of active IL-1 β (Latz et al., 2013). In C57BL/6 mice infected with a nonhealing L.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research