Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

ConclusionEach fractionation scheme induced different lymphoid and myeloid responses as well as various modulations of PD-L1 and TIGIT expression. Furthermore, 3x8Gy was the most effective protocol when associated with anti-PD-L1 and anti-TIGIT. This is the first study combining RT and anti-TIGIT with promising results; further studies are warranted.

http://link.springer.com/10.1186/s40425-019-0634-9

Source: Journal for Immunotherapy of Cancer - June 24, 2019 Category: Cancer & Oncology Source Type: research