The blockade of the serotoninergic receptors 5-HT5A, 5-HT6 and 5-HT7 in the basolateral amygdala, but not in the hippocampus facilitate the extinction of fear memory.

The blockade of the serotoninergic receptors 5-HT5A, 5-HT6 and 5-HT7 in the basolateral amygdala, but not in the hippocampus facilitate the extinction of fear memory. Behav Brain Res. 2019 Jun 21;:112055 Authors: de Assis Brasil ES, Guerino Furini CR, da Silva Rodrigues F, Nachtigall EG, Kielbovicz Behling JA, Saenger BF, Farias CP, de Carvalho Myskiw J, Izquierdo I Abstract Extinction is the learned inhibition of retrieval. It is the mainstay of exposure therapy, which is widely used to treat drug addiction, phobias and fear-related pathologies such as post-traumatic stress disorder. The serotonin (5-HT) system is positioned to modulate the extinction circuitry via ascending 5-HT projections that innervate certain brain structures including the hippocampus and the basolateral amygdala (BLA). The most recently described serotoninergic receptors 5-HT5A, 5-HT6, 5-HT7 affect different memory processes and so are putative therapeutic targets for disorders related to cognition; however, their role in the extinction of contextual fear conditioning (CFC) has not been studied yet. Here we investigate the role of these receptors in the CA1 region of the hippocampus and the BLA in the extinction of CFC. For this, male rats were implanted with cannulae in the CA1 or in the BLA region through which they received immediately or 3 h after extinction training of CFC infusions of SB699551 (10 µg/side), 5-HT5A antagonist; WAY-208466 (0.04 &micr...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

Related Links:

The current study aimed to investigate the rate of posttraumatic stress disorder (PTSD) as well as the relationship between PTSD and depressive symptoms, burnout, and life satisfaction in Turkish firefighters. A cohort of 100 male firefighters (mean age 45...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Exposure to natural disasters can lead to both negative and positive mental health consequences (i.e., posttraumatic stress disorder [PTSD] and posttraumatic growth [PTG]). While there is evidence linking metacognition to these outcomes, the focus is mostl...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news
We present prevalence rates, along with demographic and economic characteristics associated with elevated depressive symptoms (EDS), in a nationally representative sample of hired crop workers in the United States. We analyzed in-person interviews with 3,6...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
OBJECTIVE From the global views to analyze the status and trends of injury burden in China,to provide reference for injury prevention and control decision-making in China. METHODS Using the data of the GBD 2017,compared and analyzed the injury burd...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Could a chatbot, an online community, or a telepsychiatry solution offer meaningful help for people who are fighting mental health issues? Could virtual reality, artificial intelligence, or genetics appear as elements of assistance in the toolkit of medical professionals in the fields dealing with the human psyche? While we agree that medical fields requiring the most empathy and human touch will most probably not be swept away by new innovations, we looked thoroughly at how technology will appear in the future of psychiatry. Perhaps even help heal the cursed prince from Beauty and the Beast? The human touch is indispen...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Virtual Reality in Medicine AI apps AR artificial intelligence digital health digital health technologies health apps Innovation mental health psychiatry psychology technology VR Source Type: blogs
The evolution of VR hardware and software What’s the best VR will do VR, AR, MR or spatial computing? The potential of interactive immersive reality Challenges and obstacles in adoption How will immersive reality transform everyday life? What was the last time you met sci-fi? The dark side of technology Imagine that a doctor sits down in Starbucks, places some glasses on his head, instantly invokes five screens and starts doing his diagnostic work. Robert Scoble, virtual reality expert, and tech evangelist believes that will be possible in the coming years – sooner than we might think. He told us why his wi...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Great Thinkers AR augmented reality future HoloLens Innovation MR Oculus technology virtual virtual reality VR XR Source Type: blogs
Stereoelectroencephalography (SEEG) vs.Mindstrong HealthMood Monitoring via Invasive Brain Recordings or Smartphone SwipesWhich Would You Choose?That's not really a fair question. The ultimate goal of invasive recordings is one of direct intervention, by delivering targeted brain stimulation as a treatment. But first you have to establish a firm relationship between neural activity and mood. Well, um, smartphone swipes (the way you interact with your phone) aim to establish a firm relationship between your “digital phenotype” and your mood. And then refer you to an app for a precision intervention. Or to your t...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
Panic Disorders Panic Disorders are a form of anxiety. They are sudden and repeated attacks of fear that last for several minutes or longer. According to the National Institute of Mental Health, panic attacks are characterized by a fear of disaster or of losing control even when there is no real danger. A person may also have a strong physical reaction during a panic attack, and they are often confused with having a heart attack since symptoms are very similar. Panic attacks can occur at any time, and many people with panic disorders worry about and dread the possibility of having another attack. Symptoms of a panic attack...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Anxiety PTSD anxiety and addiction anxiety medication benzodiazepines general anxiety disorder managing anxiety Source Type: blogs
The findings could help with new treatments for depression, anxiety, post-traumatic stress disorder and addictions. → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Depression subscribers-only Source Type: blogs
AbstractPurpose of ReviewThis review provides an overview of the current evidence base for and clinical applications of the use of virtual reality (VR) in psychiatric practice, in context of recent technological developments.Recent FindingsThe use of VR in psychiatric practice shows promise with much of the research demonstrating clinical effectiveness for conditions including post-traumatic stress disorder, anxiety and phobias, chronic pain, rehabilitation, and addictions. However, more research is needed before the use of VR is considered a clinical standard of practice in some areas.SummaryThe recent release of first ge...
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research
More News: Addiction | Brain | Neurology | Phobias | Post Traumatic Stress Disorder | Training | Universities & Medical Training