A comprehensive exploration of the genetic legacy and forensic features of Afghanistan and Pakistan Mongolian-descent Hazara

Publication date: Available online 25 June 2019Source: Forensic Science International: GeneticsAuthor(s): Guanglin He, Atif Adnan, Allah Rakha, Hui-Yuan Yeh, Mengge Wang, Xing Zou, Jianxin Guo, Muhammad Rehman, Abulhasan Fawad, Pengyu Chen, Chuan-Chao WangAbstractAfghanistan and Pakistan are rich with a complex landscape of culture, linguistics, ethnicity and genetic legacy at the crossroads between Indian-Subcontinent and Central Asia. Hazara people have historically been suggested to be Mongolian decedents but seldom been genetically studied. To dissect the genetic structure and explore the forensic characteristics of Hazara people, we first genotyped 30 Insertion/deletion (Indel) markers in 468 samples from 2 aboriginal Hazara populations from Afghanistan and Pakistan, and 100 East Asian comparative Bouyei samples using the Investigator® DIPplex kit. Subsequently, we carried out a comprehensive population genetic analysis from four different datasets: 8,895 30-Indel genotype data from 51 populations, 15,895 30-Indel allele frequency data from 98 populations, 1,048 genotypes of 993 STRs and Indels from 53 HGDP populations and 2,068 whole-genomes (621,799 single nucleotide polymorphisms) from 165 worldwide Human origin reference populations, to further unravel the genetic complexity between Hazara and worldwide human populations using various statistical analysis. We find that 30 Indels are in accordance with HWE, and informative and polymorphic in both Central Asians Hazar...
Source: Forensic Science International: Genetics - Category: Forensic Medicine Source Type: research