Interrelationship between oxidative stress, DNA damage and cancer risk in Diabetes (Type 2) in Riyadh, KSA

Publication date: Available online 24 June 2019Source: Saudi Journal of Biological SciencesAuthor(s): Manal Abudawood, Hajera Tabassum, Mir Naiman Ali, Basmah Almaarik, Mohrah Alshaikh, Anas Dhaifallah AlGhamdi, Johara Yahya AlFaifi, Khalil Ibrahim Softa, Samia Sobki, Ali AljohiAbstractType 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiology underlying T2DM. Besides, oxidative stress can result in DNA damage leading to high cancer risk. Current study aimed to evaluate status of oxidative damage, damage to DNA and cancer biomarkers in regard to increased glucose in T2DM patients and to correlate the glycemic state with cancer. A total of 150 subjects consisting of control (50) and T2DM patients (100) were enrolled. Additionally, three tertiles were created among the two groups based on levels of HbA1c (Tertile I=5.37±0.34, n=50; Tertile II=6.74±0.20, n=50; Tertile III=9.21±1.47, n=50). Oxidative stress parameters including malondialedehyde (MDA) and antioxidant enzymes were measured. Damage to DNA was analyzed by measuring the levels of DNA damage adduct-8 hydroxy deoxy Guanosine (8-OHdG). To detect cancer resulting from oxidative stress, cancer biomarkers CEA, AFP, CA125, CA-15, CA19-9, prolactin were measured in these subjects. All...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research