Interrelationship between oxidative stress, DNA damage and cancer risk in Diabetes (Type 2) in Riyadh, KSA

Publication date: Available online 24 June 2019Source: Saudi Journal of Biological SciencesAuthor(s): Manal Abudawood, Hajera Tabassum, Mir Naiman Ali, Basmah Almaarik, Mohrah Alshaikh, Anas Dhaifallah AlGhamdi, Johara Yahya AlFaifi, Khalil Ibrahim Softa, Samia Sobki, Ali AljohiAbstractType 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiology underlying T2DM. Besides, oxidative stress can result in DNA damage leading to high cancer risk. Current study aimed to evaluate status of oxidative damage, damage to DNA and cancer biomarkers in regard to increased glucose in T2DM patients and to correlate the glycemic state with cancer. A total of 150 subjects consisting of control (50) and T2DM patients (100) were enrolled. Additionally, three tertiles were created among the two groups based on levels of HbA1c (Tertile I=5.37±0.34, n=50; Tertile II=6.74±0.20, n=50; Tertile III=9.21±1.47, n=50). Oxidative stress parameters including malondialedehyde (MDA) and antioxidant enzymes were measured. Damage to DNA was analyzed by measuring the levels of DNA damage adduct-8 hydroxy deoxy Guanosine (8-OHdG). To detect cancer resulting from oxidative stress, cancer biomarkers CEA, AFP, CA125, CA-15, CA19-9, prolactin were measured in t...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research

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Background: Whether human insulin may affect lung cancer risk requires investigation. Methods: All patients with a diagnosis of diabetes mellitus from 1996 to 2009 were enrolled from Taiwan’s National Health Insurance. An entry date was set on January 1, 2004 and 1,007,617 patients with type 2 diabetes mellitus diagnosed before 2004 were followed up for new-onset lung cancer until December 31, 2009. Incidence rates of lung cancer for never-users, ever-users and tertiles of three dose-response exposure parameters (i.e., time since starting insulin, cumulative dose and cumulative duration) were calculated. Adjusted ha...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionPre-existing diabetes contributes to poorer all-cause mortality among CRC patients and increased mortality from CRC among those with diabetes and complications. Opportunities exist to incorporate diabetes prevention and management interventions during CRC treatment phases among older adults.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Publication date: Available online 6 July 2019Source: Pathology - Research and PracticeAuthor(s): Gao-Min Liu, Hua-Dong Zeng, Cai-Yun Zhang, Xu Ji-WeiAbstractAccumulating evidence indicates a strong correlation between type 2 diabetes mellitus (T2DM) and hepatocellular carcinoma (HCC), but the underlying pathophysiology is still elusive. We aimed to identify unrecognized but important genes and pathways related to T2DM and HCC by bioinformatic analysis. The GSE64998 and GSE15653 datasets (for T2DM), the GSE121248 dataset and the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset (for HCC) were downloade...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This study focuses on assessing metformin association with lung cancer as reported in the literature. Recent studies and reviews investigating metformin effects on lung cancer incidence and patient survival are critically and systematically discussed.
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Review Article: Lung Cancer Source Type: research
ConclusionTea consumption, except for very hot tea, seems generally safe at usual levels of intake, with summary estimates indicating the largest reduction for diverse health outcomes at two to three cups per day. Generally, tea consumption seems more beneficial than harmful in this umbrella review. Randomized controlled trials are further needed to understand whether the observed associations are causal.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Review Source Type: research
ConclusionThe present SR provides state-of-the-art information about the use of metabolomics as an approach to understanding the dynamics of metabolic processes involved in human obesity and emphasizes metabolic signatures related to obesity phenotypes.
Source: Metabolomics - Category: Biology Source Type: research
Pancreatic cancer is one of the most lethal diseases. In pancreatic cancer development and progression, genetic (gene mutations and activation of oncogenes) and environmental factors (smoking, alcohol consumption, type 2 diabetes mellitus, obesity) play an essential role. Recently, molecular studies revealed that dysbiosis of microbiota also has influence on cancer development. Research indicates that bacteria and viruses can lead to chronic inflammation, antiapoptotic changes, cell survival, and cell invasion. This review presents bacteria and viruses oncogenic for the pancreas. Possible mechanisms of carcinogenic action are also described.
Source: Gastroenterology Clinics of North America - Category: Gastroenterology Authors: Source Type: research
AbstractAimsTo determine the potential risk factors and construct the predictive model of diabetic risk among a relatively low risk middle-aged and elderly Chinese population.MethodsInformation of participants was collected in the Dongfeng-Tongji cohort study, a perspective cohort study of Chinese occupational population. The main outcome was incident type 2 diabetes (T2DM). Based on the conventional risk factors of diabetes, we defined low risk participants without underlying diseases such as coronary heart disease, stroke, cancer, dyslipidemia, hypertension, metabolic syndrome, obesity and family history of diabetes. Tot...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Commentary Source Type: research
This study showed the overall presence of the obesity paradox in stroke patients with T2DM. However, obese patients had different risks of cardiovascular events and stroke.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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