Exploratory locomotion, a predictor of addiction vulnerability, is oligogenic in rats selected for this phenotype [Neuroscience]

Artificially selected model organisms can reveal hidden features of the genetic architecture of the complex disorders that they model. Addictions are disease phenotypes caused by different intermediate phenotypes and pathways and thereby are potentially highly polygenic. High responder (bHR) and low responder (bLR) rat lines have been selectively bred (b)...

Source: Proceedings of the National Academy of Sciences - June 24, 2019 Category: Science Authors: Zhifeng Zhou, Peter Blandino, Qiaoping Yuan, Pei-Hong Shen, Colin A. Hodgkinson, Matti Virkkunen, Stanley J. Watson, Huda Akil, David Goldman Tags: PNAS Plus Source Type: research