PRCD is essential for high-fidelity photoreceptor disc formation [Neuroscience]

Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has remained enigmatic despite multiple demonstrations that its mutations cause blindness in humans and dogs. Here, we generated a PRCD knockout mouse and observed a...

http://www.pnas.org/content/116/26/13087.short?rss=1

Source: Proceedings of the National Academy of Sciences - June 24, 2019 Category: Science Authors: William J. Spencer, Jin-Dong Ding, Tylor R. Lewis, Chen Yu, Sebastien Phan, Jillian N. Pearring, Keun-Young Kim, Andrea Thor, Rose Mathew, Joan Kalnitsky, Ying Hao, Amanda M. Travis, Sondip K. Biswas, Woo-Kuen Lo, Joseph C. Besharse, Mark H. Ellisman, Dan Tags: PNAS Plus Source Type: research