microRNAs in bicuspid aortic valve associated aortopathy: Recent advances and future perspectives.

microRNAs in bicuspid aortic valve associated aortopathy: Recent advances and future perspectives.
J Cardiol. 2019 Jun 20;:
Authors: Pulignani S, Borghini A, Andreassi MG
Abstract
The risk of acute aortic events in patients with bicuspid aortic valve (BAV) constitutes a medical concern in terms of timing and surgical decision. During the past years, there has been a growing interest in the potential of microRNAs (miRNAs) as crucial epigenetic factors in multiple cellular processes associated with BAV aortopathy. Nevertheless, there are still challenges that need to be overcome before miRNAs could enter clinical practice, and further validation studies in larger and well-defined BAV cohorts are now required. This review aims at providing a comprehensive overview of the available data on the expression profiles and function of specific miRNAs in BAV aortopathy, evaluating miRNA signatures as potential molecular markers of disease. We also discuss the role of other novel classes of non-coding RNAs, including long non-coding RNAs and circular RNAs, in BAV-associated aortopathy, mainly regarding their possible implementation as diagnostic and prognostic markers.
PMID: 31230901 [PubMed - as supplied by publisher]

Source: Journal of Cardiology - June 19, 2019 Category: Cardiology Authors: Pulignani S, Borghini A, Andreassi MG Tags: J Cardiol Source Type: research