Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus ‐like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis

ConclusionWe have demonstrated that inhibition of glutaminolysis represents a potential new treatment strategy for patients with SLE and Th17 ‐related autoimmune diseases. Mechanistically we have shown that inhibition of glutaminolysis affects the glycolysis pathway by reducing Hif1α protein in Th17 cells.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research