Bone ‐Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment

In conclusion, romosozumab produced an early and transient increase in bone formation, but a persistent decrease in bone resorption. Antiresorptive action eventually resulted in decreased bone turnover. This effect resulted in significant increases in bone mass and improved microarchitecture.

Source: Journal of Bone and Mineral Research - June 23, 2019 Category: Orthopaedics Authors: Pascale Chavassieux, Roland Chapurlat, Nathalie Portero ‐Muzy, Jean‐Paul Roux, Pedro Garcia, Jacques P Brown, Cesar Libanati, Rogely W Boyce, Andrea Wang, Andreas Grauer Tags: ORIGINAL ARTICLE Source Type: research