Sickle cell disease and infections in high- and low-income countries

Infections, especially pneumococcal septicemia, meningitis, andSalmonella osteomyelitis, are a major cause of morbidity and mortality in patients with sickle cell disease (SCD). SCD increased susceptibility to infection, while infection leads to SCD-specific pathophysiological changes. The risk of infectious complications is highest in children with a palpable spleen before 6 months of age. Functional splenectomy, the results of repeated splenic infarctions, appears to be an important host-defense defect. Infection is the leading cause of death, particularly in less developed countries. Defective host-defense mechanisms enhance the risk of pneumococcal complications. Susceptibility toSalmonella infections can be explained at least in part by a similar mechanism. In high-income countries, the efficacy of the pneumococcal vaccine has been demonstrated in this disease. A decreased in infection incidence has been noted in SCD patients treated prophylactically with daily oral penicillin. Studies in low-income countries suggest the involvement of a different spectrum of etiological agents.
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research

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Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global health Vaccines and immunisation United Nations MMR Polio Global development Society World news Source Type: news
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
In conclusion, co-infection of chicks with AIV and IBV, simultaneously or sequentially, affected the clinical signs, the virus replication dynamics as well as the internal organ integrity. The results proposed that infection with heterologous virus may result in temporary competition for cell receptors or competent cells for replication, most likely interferon-mediated. PMID: 31300117 [PubMed - in process]
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
ConclusionsMultiple site of infection ,sever osteomylitis, and delay in fever response consolidated the fact of high virulence of salmonella in SCD patients. We do not encounter significant resistant rate to both quinolone and cephalosporin.
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
IntroductionThe incidence of invasive pneumococcal infections in patients with sickle cell disease (SCD) decreased after introduction of penicillin prophylaxis and pneumococcal conjugate vaccine (PCV). However, the decrease in pneumococcal infections alone may not necessarily mean an overall decrease in severe bacterial infections (SBI). In a previous publication, we reported a 0.4 % prevalence of pneumococcal bacteremia following introduction of PCV 13. In the current study, we aimed to define the prevalence of SBI and hospitalization in febrile patients in the same cohort in the later years.MethodsWe performed a retrospe...
Source: Blood - Category: Hematology Authors: Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster III Source Type: research
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Source: Blood - Category: Hematology Authors: Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster III Source Type: research
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Source: Journal of Paediatrics and Child Health - Category: Pediatrics Authors: Tags: Review Article Source Type: research
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Source: Annals of Saudi Medicine - Category: Journals (General) Tags: ISSUE 3 Source Type: research
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