Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3 α signaling pathway in C2C12 myotubes and mice.

In conclusion, matrine can alleviate muscle atrophy and improve myoblast differentiation possibly by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway. PMID: 31233199 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31233199?dopt=Abstract

Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research