Misregulation of Mitochondrial Protein Synthesis Leads to Cardiomyopathy

Mitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases.

Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: L. Hughes, D. Rudler, K. Perks, T. Richman, I. Kusnetsova, J. Ermer, A. Shearwood, H. Viola, L. Hool, S. Siira, O. Rackham, A. Filipovska Tags: 035 Source Type: research