Cancers, Vol. 11, Pages 884: Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the Ovary

In conclusion, loss of a single gene (PTEN) allows the fallopian tube epithelia to form MTS, which survive better under ultra-low adhesion conditions, attach to the extracellular matrix exposed during ovulation, and colonize the ovary. These results suggest that MTS may contribute to seeding of the ovary in HGSOC patients.

Source: Cancers - June 24, 2019 Category: Cancer & Oncology Authors: Matthew Dean Vivian Jin Tova M. Bergsten Julia R. Austin Daniel D. Lantvit Angela Russo Joanna E. Burdette Tags: Article Source Type: research