Multiple primary malignancies associated with a germline SMARCB1 pathogenic variant
AbstractA 51-year old presented with a 6-month history of increasing pelvic/lower back pain with nocturnal waking and episodes of anorexia and vomiting. Examination revealed right torticollis and Horner ’s syndrome, and a large abdominal mass arising from the pelvis. Magnetic resonance and positron emission tomography imaging revealed (A) a 14 cm heterogeneous enhancing mass, abutting the left kidney with standardised uptake value max = 2.9, (B) a large heterogeneous enhancing pelvic mass (C ) mesenteric adenopathy standardised uptake value max = 10.3 and (D) 6 cm right lung apex mass standardised uptake value max = 4.3. Computerised tomography-guided biopsy of lesion A was reported as neurofibroma with occasional atypia, lesion B a benign uterine leiomyoma and lesion C follicu lar lymphoma world health organisation Grade 2. Although she had been given the diagnosis of Neurofibromatosis Type-1 (NF1) 25-years previously following removal of an intradural extramedullary schwannoma she had no cutaneous stigmata of NF1. Genetic analysis of blood lymphocyte DNA identified a pat hogenic variant inSMARCB1 confirming a diagnosis of schwannomatosis. Following 6-months chemotherapy for lymphoma, surgery was performed to remove lesion A. Histology revealed a malignant peripheral nerve sheath tumour with areas of low and high-grade change. An incidental, well-differentiated small bowel neuroendocrine carcinoma was also excised. Cl...
In an Appalachian town, an unlikely group of activists recognized the early stages of the deadly drug epidemic, and fought in vain to stem its rise.
A computer-based simulation model projected that CT lung screening in several...Read more on AuntMinnie.comRelated Reading: Biennial follow-up exams prove safe for CT lung screening Lung cancer imaging on the upswing in China CT lung screening spots cancers earlier in China CT lung screening cuts cancer mortality 51% in Japan CT lung screening may benefit racial minorities most
The U.S. Congress passed a law in 2014 to reduce unnecessary MRI exams, CT...Read more on AuntMinnie.comRelated Reading: CDS prompts appropriate advanced imaging orders Walmart charts new course by steering workers to high-quality imaging centers CDS reduces inappropriate imaging in the ED Medicare's AUC/CDS mandate will begin next year Can local use guidelines reduce inappropriate imaging?
For its fiscal year that ended June 30, the Little Rock cancer treatment provider reported a $3.5 million operating income before depreciation.
It doesn't shy away from murder ballads or real life... ... If we sweep pain and wrong under the rug, there's no opportunity for healing and change." ... You are leaving AARP.org and going to the w...
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Abdul Wahab Jatoi, Ick Soo Kim, Hiroshi Ogasawara, Qing-Qing NiAbstractAlthough silver based nanofibers possess excellent bactericidal and bacteriostatic characteristics. However, excess release/contact with silver may induce harmful side-effects including carcinoma, argyria, argyrosis and allergies. Similarly, silver depletion may limit prolonged antibacterial activities as well. Thus present research proposes electrospun CA/ZnO/AgNPs composite nanofibers for biologically safer and sustained antibacterial applications. The Zn...
ConclusionsOverall HCAHPS satisfaction scores following lung resection for cancer were high and negatively associated with increasing length of stay. Patient satisfaction may be impacted more by the perception of effective communication during prolonged hospitalizations than by complications.
More News: Anorexia | Back Pain | Brain | Cancer | Cancer & Oncology | Cancer of the Uterus | Carcinoma | Chemotherapy | Computers | Eating Disorders & Weight Management | Genetics | Leiomyoma | Low Back Pain | Lymphoma | Neurofibromatosis | Neurology | Neurosurgery | Pain | PET Scan | Study | Urology & Nephrology | WHO