Altered Cellular White Matter But Not Extracellular Free Water on Diffusion MRI in Individuals at Clinical High Risk for Psychosis.

CONCLUSIONS: Cellular but not extracellular alterations characterized the clinical high-risk group, especially in those who experienced a decline in functioning. These cellular changes suggest an early deficit that possibly reflects a predisposition to develop attenuated psychotic symptoms. In contrast, extracellular alterations were not observed in this clinical high-risk sample, suggesting that previously reported extracellular abnormalities may reflect an acute response to psychosis, which plays a more prominent role closer to or at onset of psychosis.
PMID: 31230461 [PubMed - as supplied by publisher]

Source: The American Journal of Psychiatry - June 23, 2019 Category: Psychiatry Authors: Tang Y, Pasternak O, Kubicki M, Rathi Y, Zhang T, Wang J, Li H, Woodberry KA, Xu L, Qian Z, Zhu A, Whitfield-Gabrieli S, Keshavan MS, Niznikiewicz M, Stone WS, McCarley RW, Shenton ME, Wang J, Seidman LJ Tags: Am J Psychiatry Source Type: research