A simple screening test for the detection of erythropoietin antibodies.

A simple screening test for the detection of erythropoietin antibodies.
Clin Nephrol. 2013 Feb 8;
Authors: Meran S, Wonnacott A, Davies M, Ellis R, Phillips A
Abstract
Antibody-mediated pure red cell aplasia (PRCA) is a rare complication of erythropoietin (EPO) therapy. Identification and demonstration of functional activity of EPO antibodies required to diagnose this condition is difficult and only performed in selected laboratories worldwide. In this article we report a recent cluster of three cases of antibody-mediated PRCA over a 16-month period in a single center associated with EPREX use. We also describe the use of a simple low-cost inhibitor assay that can be used to screen for PRCA in local laboratories.
PMID: 23391321 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - February 8, 2013 Category: Urology & Nephrology Authors: Meran S, Wonnacott A, Davies M, Ellis R, Phillips A Tags: Clin Nephrol Source Type: research