GSE102643 Identification of the coiled-coil domain as an essential element of MBD3 for preserving lineage commitment potential of ESCs

Contributors : Masataka Hirasaki ; Masakazu Kohda ; Yasushi Okazaki ; Akihiko OkudaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAs one of approaches for elucidating the molecular bases which define the difference for counteracting defect of Mbd3-knockout ESCs between MBD3a mutant lacking MBD domain and that lacking coiled-coil domain, we explored the possibility that these two mutants are different in their ability to recruit PRC2 complex in close vicinity by ChIP-sequence analyses.

Source: GEO: Gene Expression Omnibus - June 25, 2019 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research