Management of high-risk medulloblastoma.

Management of high-risk medulloblastoma.
Neurochirurgie. 2019 Jun 20;:
Authors: Bouffet E
Abstract
Medulloblastoma is the most common malignant brain tumors in children. Current management combine surgery, radiotherapy, and chemotherapy. Current treatment of medulloblastoma is based on a clinical risk-stratification system that takes into account age, extent of resection and metastatic status. High risk medulloblastoma patients are defined by the presence of metastatic disease and/or an incomplete resection with a residual amount of tumour > 1.5 cm2. This review describes the evolution in the management of high risk medulloblastoma patients during recent 4 decades and recent changes in the definition of high risk patients as a result of major advances in the understanding of the molecular heterogeneity of medulloblastomas.
PMID: 31229532 [PubMed - as supplied by publisher]

Source: Neuro-Chirurgie - June 19, 2019 Category: Neurosurgery Authors: Bouffet E Tags: Neurochirurgie Source Type: research