New immune checkpoint explored for head and neck cancer

(Medical College of Georgia at Augusta University) A checkpoint may delay travelers but it can help give cancer free rein by suppressing the natural immune response that should destroy it, researchers say.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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AbstractHead and neck squamous cell carcinoma (HNSCC) develops in the mucosal lining of the upper aerodigestive tract, principally as a result of exposure to carcinogens present in tobacco products and alcohol, with oncogenic papillomaviruses also being recognized as etiological agents in a limited proportion of cases. As such, there is considerable scope for prevention of disease development and progression. However, despite multimodal approaches to treatment, tumor recurrence and metastatic disease are common problems, and clinical outcome is unsatisfactory. As our understanding of the genetics and biochemical aberration...
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 17 July 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Katie Suzanne Traylor, Nicholas Koontz, Kristine MosierAbstractThe incidence of head and neck cancer continues to rise annually, most commonly squamous cell carcinoma (SCCa). Advances in imaging techniques have improved diagnostic accuracy with important ramifications for initial staging and post-treatment surveillance. FDG-PET/CT and, more recently, FDG-PET/MRI have revolutionized the staging and surveillance of head &neck SCCa. We detail the diagnostic role of FDG-PET/CT and FDG-PET/MRI of SCCa at the different head an...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
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Source: Expert Opinion on Biological Therapy - Category: Drugs & Pharmacology Authors: Source Type: research
Checkpoint immunotherapy has revolutionised the way that melanoma is treated and has also shown significant effectiveness in lung, bladder, renal, and head and neck cancers. At the present time, trials of checkpoint immunotherapy in cervical cancer are at early phases, but there is very good rationale for pursuing this as a treatment option, especially as cervical cancer is a virally driven cancer and therefore should be recognised by the immune system as being foreign. This review explores the biomarkers for the selection of patients for immunotherapy in other cancers, such as programmed death ligand 1 (PD-L1) expression,...
Source: Clinical Oncology - Category: Radiology Authors: Tags: Overview Source Type: research
CONCLUSION: CCRT should be considered standard of care in those over seventy with good performance status. Patients with tube dependence have a higher risk of persistent disease or treatment related mortality.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
HS Darling, S Jayalakshmi, Pradeep JaiswalIndian Journal of Cancer 2019 56(3):267-268
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
This cross-sectional survey study evaluates the outcomes of voice changes following surgery in patients with thyroid cancer.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
In Reply We appreciate Dr Chow ’s interest in our study. We agree that having a central lymph node dissection might affect patients’ reported health-related quality of life (HRQOL). In our cohort, 29% of those who had a total thyroidectomy had concurrent central lymph node dissection. We have now further explored whether this affected the association between thyroidectomy and HRQOL in 2 ways. First, we included this as a variable in our multivariable analyses. Compared with having a hemithyroidectomy, we found that the association between having a total thyroidectomy and reporting an HRQOL issue was similar whe...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
To the Editor We read with interest the article by Nickel et al. The results of the study indicated that patients with differentiated thyroid cancer (DTC) treated by hemithyroidectomy enjoyed better quality of survival and fewer complications than those by total thyroidectomy. The authors recommended that hemithyroidectomy might be a more appropriate surgical therapy for small, localized DCT.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
CONCLUSION: C-ion RT using compact rotating gantry and 3-dimentional active scanning is a safe and feasible treatment for relatively less mobile tumours. ADVANCES IN KNOWLEDGE: This study will be the first step to establish the use of superconducting rotating gantry in carbon ion radiotherapy in clinical setting paving the way for treating large number of patients and make it a standard of practice in the future. PMID: 31317764 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
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