Cranial and intra-axial metastasis originating from a primary ovarian Dysgerminoma

Publication date: Available online 22 June 2019Source: Gynecologic Oncology ReportsAuthor(s): Tiffany L. Beck, Hitomi Momose, Jeffrey M. Dym, Vikas Y. Rao, Randy Bohart, Bram H. GoldsteinAbstractDysgerminomas are aggressive germ cell tumors that typically have a favorable prognosis, especially in patients diagnosed with early stage disease. We recount the history of a 23-year-old woman who was treated for a stage IA ovarian dysgerminoma in November 2017. Postoperatively, the patient was noncompliant insofar as obtaining routine lab evaluations; ten months later, she was diagnosed with a cranial metastasis that extended into the meninges. The patient subsequently underwent a posterior fossa craniotomy and adjuvant etoposide, bleomycin and cisplatin chemotherapy to which she initially responded; however, during cycle 4, she developed pancytopenia whereupon the chemotherapy was summarily discontinued. Thereafter, the patient was surveilled and currently, she remains in clinical remission. Early stage ovarian dysgerminoma, albeit rarely, has the capacity to metastasize to the cranium or brain, further underscoring the significance of employing active follow-up with these patients.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research

Related Links:

In conclusion, OnTRAF5 participate in anti-bacteria immune response and is crucial for the signaling transduction.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
ConclusionOur research suggests the experimental evidence for DFO and CDDP as a new effective combination therapy to enhance the efficacy of chemical therapy in ovarian cancer.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ02818H, PaperTao Ren, Zhiwei Deng, Hui Liu, Xiufang Li, Jianbing Li, Jing Yuan, Yao He, Qi Liu, Yanjing Yang, Shian Zhong Engineering of a DNA tetrahedron allows co-delivery of DOX and DNAzyme for chemo-gene synergistic therapy aiming at specific cells and their microenvironment. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
We report the in-water synthesis of a novel keratin-based nanoformulation for the co-delivery of the antimitotic Docetaxel (DTX) and the photosensitizer Chlorin e6 (Ce6). The drug-induced aggregation method allowed the formation of monodisperse NPs (DTX/Ce6-KNPs) with an average diameter of 133 nm and loaded with a drug ratio of 1:1.8 of Ce6 vs DTX. The efficacy of DTX/Ce6-KNPs was investigated in vitro in monolayers and spheroids of DTX-sensitive HeLa (HeLa-P) and DTX-resistant HeLa (HeLa-R) cells. In monolayers, the cytotoxic effects of DTX/Ce6-KNPs toward HeLa-P cells were comparable to those induced by free DTX +...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Abstract PURPOSE: To evaluate the use of individualized piano instruction (IPI) for improving cognition among breast cancer survivors. PARTICIPANTS & SETTING: Six participants were included in an eight-week piano program with three data collection time points at baseline, midpoint, and postintervention. Participants were recruited from the breast cancer clinic of a university cancer center in South Florida. METHODOLOGIC APPROACH: Neurocognitive, psychosocial, and self-report assessments were conducted to determine potential benefits and program feasibility, including the NIH Toolbox® Cognition Ba...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
Abstract PROBLEM IDENTIFICATION: This review identifies specific cardiotoxicity related to anthracycline chemotherapy, specific risk factors related to increased anthracycline chemotherapy-induced cardiotoxicity, and underlying mechanisms of action of anthracycline chemotherapy-induced cardiotoxicity. LITERATURE SEARCH: PubMed®, CINAHL®, Embase®, and Web of Science were searched in May 2018 using keywords related to heart diseases, anthracycline chemotherapy, and breast cancer. DATA EVALUATION: Data were extracted, and study quality was assessed according to PRISMA (Preferred Reporting Items ...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
Condition:   Colorectal Cancer Interventions:   Drug: Chemotherapy;   Procedure: Radiofrequency ablation (RFA);   Drug: In situ immunotherapy Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stage IIIA Non-small Cell Lung Cancer;   Stage IIIB Non-small Cell Lung Cancer Interventions:   Drug: Durvalumab;   Procedure: Surgery;   Radiation: Radiotherapy Sponsors:   Alliance Foundation Trials, LLC.;   AstraZeneca Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Gastric Cancer;   Adenocarcinoma of the Esophagogastric Junction Interventions:   Drug: Nivolumab;   Drug: Ipilimumab;   Drug: Relatlimab;   Drug: Oxaliplatin;   Drug: Docetaxel;   Drug: 5-Fluorouracil;   Drug: Folic acid Sponsors:   Jan Ellermeier;   GWT-TUD GmbH Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Lung Non-Small Cell Carcinoma;   Stage I Lung Cancer AJCC v8;   Stage IA1 Lung Cancer AJCC v8;   Stage IA2 Lung Cancer AJCC v8;   Stage IA3 Lung Cancer AJCC v8;   Stage IB Lung Cancer AJCC v8;   Stage II Lung Cancer AJCC v8;   Stage IIA Lung Cancer AJC C v8;   Stage IIB Lung Cancer AJCC v8;   Stage IIIA Lung Cancer AJCC v8 I...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Brain | Brain Cancers | Cancer & Oncology | Chemotherapy | Craniotomy | Dysgerminoma | Germ Cell Tumors | Men | Neurology | OBGYN | Ovaries | Pancytopenia