Boy, 1, thriving after groundbreaking surgery in the WOMB to treat spina bifida
When Charley's condition first became apparent on the 13-week scan, California sweethearts Lexi and Joshuwa Royer were advised to consider abortion. But they heard about a new experiment.
CONCLUSION: Fetoscopic MMC repair has no detectable effects on brain microstructure when compared to babies repaired by an open hysterotomy technique. Carbon dioxide insufflation of the uterine cavity during fetoscopy does not seem to have any isolated deleterious effects in fetal brain microstructure. This article is protected by copyright. All rights reserved. PMID: 31219638 [PubMed - as supplied by publisher]
CONCLUSIONS: We have described the use of a new first trimester sonographic marker for the diagnosis of spina bifida. Our results suggest that the crash sign may be a useful tool in the first trimester detection of spina bifida. Prospective evaluation of the crash sign would be beneficial, ideally in a routine clinical screening ultrasound setting. This article is protected by copyright. All rights reserved. PMID: 30977215 [PubMed - as supplied by publisher]
Bethan Simpson, 26, of Burnham, Essex, was first advised to terminate her pregnancy when doctors discovered her baby had the birth defect spina bifida during her 20-week scan.
CONCLUSION: Babies exposed to fetoscopic or open in-utero MMC repair did not show significant differences in fetal or postnatal growth parameters. These results support the safety of the use of CO2 gas for fetoscopic surgery. This article is protected by copyright. All rights reserved. PMID: 30672627 [PubMed - as supplied by publisher]
We instituted early clean intermittent catheterization (CIC) in 1997 for all newborn infants with spina bifida (SB). We compared this group to a historical group managed expectantly to see if early catheterization was associated with a reduction in renal scar rate as determined by DMSA scanning.
Conclusion: Surgical management of the association of hydrocephalus with neural tube defect in 1 or 2 operative stages gave similar clinical results. However, the treatment in 1 surgical stage would considerably reduce the charges.Pediatr Neurosurg
Conclusions: This was the first time a case of spinal cord defect was reported in trisomy 22 fetuses. More attention should be paid to the spinal cord during sonographic examinations in trisomy 22 fetuses.
ConclusionsAvoiding valproate intake during pregnancy is likely to reduce the incidence of foetal malformation, but at a cost of worsened maternal epilepsy control. Individualization of treatment is particularly important in considering withdrawal of valproate in the light of the fact that it is much more widely used in generalized epilepsy, there being fewer alternative drugs than for focal epilepsy and withdrawal is not without risk for both mother and baby. This study may provide a quantitative basis for assessing the balance between benefit and disadvantage for individual women with valproate ‐treated epilepsy who ar...
Improved management for spina bifida has increased the number of patients transitioning to adult care. This trend increases the importance of maintaining renal function concurrently with bladder function in patients with spina bifida. Dimercaptosuccinic acid (DMSA) renal scanning is an optimal tool for investigating renal insufficiency in children with spina bifida; however, the benefits of DMSA scans in adulthood are unclear. We investigated the role of DMSA renal scans for spina bifida patients during the transition to adulthood (15 –25 years of age) to reveal their association with current renal function.
Improved management for spina bifida (SB) has increased the number of patients transitioning to adult care. This trend increases the importance of maintaining renal function concurrently with bladder function in patients with SB. Dimercaptosuccinic acid (DMSA) renal scanning is an optimal tool for investigating renal insufficiency in children with SB; however, the benefits of DMSA scans in adulthood are unclear. The role of DMSA renal scans for patients with SB during the transition to adulthood (15 –25 years of age) to reveal their association with current renal function was investigated.