Why is psychogenic nonepileptic seizure diagnosis missed? A retrospective study

ConclusionSome demographic variables (i.e., early age at the onset of seizures), patients' clinical variables (i.e., severe seizure manifestations such as ictal injury), and finally, some physician-related variables (i.e., prescribing AEDs) have significant associations with a delay in making a definite diagnosis of PNES.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Conditions:   Epilepsy in Children;   Mindfulness;   Quality of Life Intervention:   Behavioral: Making Mindfulness Matter (M3) Sponsors:   Lawson Health Research Institute;   Canadian Institutes of Health Research (CIHR) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A known cause of seizure-induced respiratory arrest is the deficiency in serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan. A recent study revealed a reduction in TPH2 protein expression in the brainstems of DBA/1 mice that developed recurrent seizure-induced respiratory arrest, whereas the activity of this protein was unexplored. Thus this study aims to investigate the association between intrinsic 5-hydroxytryptamine synthesis in the brainstem and the susceptibility for sudden ...
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Conclusions: Our study demonstrates that a combination of bioanalytical cross-validation and clinical evaluation is an effective way to describe the applicability of DBS as an alternative to plasma, taking into account how therapeutic drug monitoring is used in specific patient groups. For LTG, converted CBZ and VPA, DBS is a feasible alternative for self-sampling at home. DBS for LEV can only be recommended for nonadherence queries due to the high variability of the plasma/DBS concentration ratios.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
ABSTRACT Objective To analyze the risk factors and prognosis related to early post-traumatic epilepsy (EPTE). Methods One hundred and eighty-six patients with traumatic brain injury were enrolled. Their full clinical data were collected. Single factor analysis and logistic regression analysis of risk factors related to EPTE were performed. The prognosis of patients was determined. Results Single factor analysis showed that there were significant differences of age (p = 0.011), epilepsy history (p
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
This study showed that vortioxetine reduces the number of acutely-induced epileptic discharges. Vortioxetine may be an important alternative for epileptic patients with major depressive disorder-related cognitive dysfunction.RESUMO A vortioxetina é um agente antidepressivo multimodal que modula os receptores 5HT e inibe o transportador de serotonina. Está indicada, principalmente nos casos de transtorno depressivo maior (TDM), relacionado à disfunção cognitiva. Existem muitos estudos que investigam os efeitos dos antidepressivos no limi ar convulsivo e na atividade epiléptica de cu...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Glucose transporter-1 (GLUT1)/SLC2A1 is expressed at the highest levels in brain capillaries, astroglia, and erythrocytes. GLUT1-deficiency syndrome is a neurological disorder resulting primarily from aberrant glucose transport into the brain. Clinically, it is classified as GLUT1-deficiency syndrome with epilepsy and without epilepsy. The phenotypic spectrum of GLUT1- deficiency syndrome expanded over last two decades, encompassing a varying combination of epilepsies (absence, atypical absence, myoclonic, myoclonic-astatic, refractory generalized epilepsy, intractable infantile epilepsy etc.), movement disorders (paroxysm...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Clinical letter Source Type: research
ConclusionsThe proposed method successfully reduces computation time of an IED detection system. Therefore, it is beneficial in speeding up IED detection especially when utilizing large EEG datasets.Graphical abstract
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Authors: Nishitani A, Yoshihara T, Tanaka M, Kuwamura M, Asano M, Tsubota Y, Kuramoto T Abstract Hyperpolarization-activated cyclic nucleotide-gated 1 (HCN1) channels contribute to spontaneous rhythmic activity in different tissues, including the heart and brain. Deficiency in HCN1 function is associated with sick sinus syndrome in mice and epilepsy in humans. We recently developed Hcn1-deficient rats and found that they exhibit absence epilepsy. While rearing Hcn1-deficient rats, we noticed loose muscle tension and abnormal gait. We therefore evaluated the muscle strength and motor functions of Hcn1-deficient rats...
Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
Publication date: Available online 12 July 2019Source: Epilepsy &BehaviorAuthor(s): Massimiliano Beghi, Cesare Maria Cornaggia, Ettore Beghi, William Curt LaFrance
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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