Experimental alcoholism primes structural and functional impairment of the glymphatic pathway
Publication date: Available online 24 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Qiang Liu, Lingli Yan, Miaodan Huang, Haitao Zeng, Senthil Kumaran Satyanarayanan, Zhe Shi, Dingbang Chen, Jia-Hong Lu, Zhong Pei, Xiaoli Yao, Huanxing SuAbstractAlcoholism is a risk factor for the development of cognitive decline and dementia. Here we demonstrated that the glymphatic function in the brain was impaired by alcohol administration. Acute moderate alcohol administration substantially retarded and reduced the entry of subarachnoid cerebrospinal fluid (CSF) via the paravascular space into the cerebral parenchyma, thus impaired CSF-interstitial fluid (ISF) exchange and parenchymal amyloid β (Aβ) peptide clearance. The elevated release of β-endorphin and reduced cerebrovascular pulsatility after acute alcohol administration may account for the impairment of the glymphatic function. Chronic moderate alcohol consumption led to pronounced activation of astrocytes and a widespread loss of perivascular AQP4 polarization in the brain, which results in an irreversible impairment of the glymphatic function. The results of the study suggest that impaired glymphatic functions and reduced parenchymal Aβ clearance found in both acute and chronic alcohol treatment may contribute to the development of cognitive decline and dementia in alcoholism.
Female military veterans with alcohol use disorder were three times more likely to develop dementia compared to their counterparts who did not engage in heavy alcohol use.Medscape Medical News
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There hasn’t been much good news about Alzheimer’s lately, between the March announcement by Biogen and Esai that a promising trial of a potential drug treatment failed, and the July decision by Novartis and Amgen to stop their study of another class of therapies for the neurodegenerative disease. But in a pair of studies presented at the annual Alzheimer’s Association International Conference on July 14, researchers reported encouraging results from studies of non-drug approaches. In one, scientists led by Dr. Klodian Dhana at Rush University Medical Center in Chicago followed nearly 2,500 people for alm...
This cohort study uses UK Biobank data to examine interactions between polygenic risk for Alzheimer disease and lifestyle (physical activity, healthy diet, moderate alcohol drinking) and their associations with incident all-cause dementia.
DiscussionOur main hypothesis is that the implementation of the intervention will lead to a decline in the prevalence of depression and a reduction in depression symptoms among the home residents. In addition, we expect the intervention to have a positive impact on secondary outcomes such as level of functioning, quality of life, and social participation. The project ’s results can make an important contribution toward improving the health care of nursing home residents who have late-life depression.Trial registrationDRKS,DRKS00015686, Oct. 10, 2018.
Brain MR images have revealed large amounts of gray-matter volume in 14-year-olds...Read more on AuntMinnie.comRelated Reading: PET, fMRI shed light on alcohol's effects on brain DTI-MRI shows drinking affects young men and women differently MRI shows that cannabis alters youth brain development MRI links lifestyle factors to stroke, dementia risk fMRI shows what makes an angry drunk
CONCLUSION Compared with overnight fasting, pre-operative carbohydrate loading did not significantly enhance peri-operative well being or recovery in patients undergoing day-case cholecystectomy. TRIAL REGISTRATION Clinicaltrials.gov Identifier: NCT03757208.
MR brain images have revealed large amounts of gray matter volume in 14-year-olds...Read more on AuntMinnie.comRelated Reading: PET, fMRI shed light on alcohol's effects on brain DTI-MRI shows drinking affects young men and women differently MRI shows that cannabis alters youth brain development MRI links lifestyle factors to stroke, dementia risk fMRI shows what makes an angry drunk
The objective of this study is to investigate the potential dose–response association between alcohol consumption and the risk of mild cognitive impairment (MCI). Methods: We will perform a dose–response meta-analysis (DRMA) of cohort studies to explore the dose–response relationship between alcohol intake and MCI. A comprehensive literature search of PubMed, EMBASE, The Cochrane Library, Chinese BioMedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Wan-Fang Database will be conducted. Two investigators will independently select studies, extract data, and assess...