Use of multivariate immune reconstitution patterns to describe immune reconstitution after allogeneic stem cell transplantation in children

The speed and quality of immune reconstitution are important factors in clinical outcomes after hematopoietic stem cell transplantation (HSCT). Immune reconstitution in this setting is a stepwise process in which the innate immune system starts to recover before the adaptive system [1]. In particular, the timing of T and B lymphocyte reconstitution has been associated with increased risks of post-transplantation opportunistic infections and transplant-related mortality in various studies [2 –7]. Further, the timing of reconstitution of the various lymphocyte subtypes and their functions are related to clinical outcomes after transplantation, in particular, the occurrence of graft-versus-host disease (GvHD), relapse of malignant disease, and infectious complications.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research