Efficacy and safety of oral deferasirox treatment for transfusional iron overload in pure red cell aplasia patients after allogeneic stem cell transplantation

Source: Annals of Hematology - Category: Hematology Source Type: research

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Authors: Han S, Sun J, He S, Tang M, Chai R Abstract Graphene-based nanocomposites have attracted more and more attention recently in the field of biology and biomedicine. Graphene and its derivatives have been integrated with drugs, nucleic acids, antibodies, and other molecules. And these materials could be use as nanocomposite carriers or scaffold materials taking advantages of their enormous specific surface area, good elasticity and ductility, excellent biocompatibility, and outstanding mechanical strength. In addition, these composites have strong near-infrared absorbance and can act as photothermal agents to...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Pierri F, Dufour C Abstract Introduction: About 60% of aplastic anemia (AA) patients are in need of further treatment after front line standard immunosuppressive therapy (IST). This along with the prolonged survival of AA subjects who do not respond to or relapse after this treatment makes management of these patients a rising and very challenging issue. Areas Covered: Literature research, carried out from the most commonly used data bases, included the following key words: aplastic anemia, immunosuppressive treatment, Anti Thymocyte Globuline, Ciclosporine A, refractory aplastic anemia, relapsing aplastic...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
AbstractPurpose of reviewThis review focuses on the findings of recent randomized prospective trials evaluating new therapeutic options for primary central nervous system lymphoma (PCNSL) in first-line treatment and on the most promising novel agents.Recent findingsThe current standard treatment of newly diagnosed PCNSL has long been depending on high-dose methotrexate (HD-MTX) –based polychemotherapy followed by whole-brain radiotherapy (WBRT). Recent randomized trials have provided evidence that high-dose chemotherapy with autologous stem cell transplantation (ASCT) is a valuable alternative option to WBRT as conso...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
Patients who undergo open heart surgeries sometimes suffer from post-operative cognitive dysfunction (POCD), which could be caused by lack of oxygen to the brain while under anesthesia. Of the roughly 500,000 patients receiving coronary artery bypass grafting procedures each year, 14–48 percent can be affected with this condition, according to David Platt, PhD, CEO of MDX Life Sciences. If the anesthesiologist notices when a patient’s brain is becoming hypoxic during surgery, steps can be taken to restore oxygen flow. However, detecting that the brain is not receiving enough oxygen is no...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Source Type: news
Condition:   Malignant Hematologic Neoplasm Intervention:   Procedure: Parenteral Nutrition/Enteral Nutrition Sponsor:   Lawson Health Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Myeloma Intervention:   Drug: Daratumumab Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Malignant Hematologic Neoplasm Intervention:   Procedure: Parenteral Nutrition/Enteral Nutrition Sponsor:   Lawson Health Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Myeloma Intervention:   Drug: Daratumumab Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, DPSCs are a potential source of stem cells in the field of eye stem cell therapy due to its protective effects against retinal degeneration.
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Hematopoietic stem cell transplantation (HSCT) is used to treat a growing number of malignant and non-malignant conditions in children and adults. The conditioning chemotherapy that patients receive in preparation for HSCT results in prolonged neutropenia and injury to mucosal surfaces, facilitating translocation of microbes across these barriers and predisposing to bloodstream infection (BSI). The most frequent causes of BSI in HSCT recipients are Enterobacteriaceae, enterococci, and viridans group streptococci [1, 2] These infections are associated with substantial morbidity and mortality, with case fatality rates of 8-6...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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