Transcriptomic network interactions in the human skin treated with topical glucocorticoid clobetasol propionate

Glucocorticoids (GCs) are the most frequently used anti-inflammatory drugs in dermatology. However, the molecular signature of GCs and their receptor (GR) in human skin is largely unknown. Our validated bioinformatics analysis of human skin transcriptome (RNASeq) induced by topical glucocorticoid clobetasol propionate (CBP) in healthy volunteers identified numerous unreported GC-responsive genes, including over a thousand non-coding RNAs. We observed sexual and racial dimorphism in the CBP response including a shift towards IFN α/IFNγ and IL6/JAK/STAT3 signaling in female skin; and a larger response to CBP in African-American skin.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research