Low Density Lipoprotein (LDL) Cholesterol as a Causal Role for Atherosclerotic Disease: Potential Role of PCSK9 Inhibitors

AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9)-related discoveries of the turn of the century have translated into substantial novelty in dyslipidemia treatment in the last 5  years. With chronic preventable atherosclerotic cardiovascular diseases (ASCVD) representing an epidemic of morbidity and mortality worldwide, low-density lipoprotein cholesterol (LDL-c) reduction represents a public health priority. By overcoming two major statin-related issues, namely intoleranc e and ineffectiveness, PCSK9 inhibitors have offered a safe and effective option in selected clinical settings where LDL-c reduction is required. Herein, we recapitulate recent findings, clinical applications, and ASCVD prevention potential of PCSK9 inhibition, with focus on anti-PCSK9 monoclonal an tibodies, evolocumab and alirocumab.
Source: High Blood Pressure and Cardiovascular Prevention - Category: Cardiology Source Type: research

Related Links:

Right now the world is experiencing an epidemic that is projected to get much, much worse. It’s an epidemic of dementia, affecting 50 million people and millions more of their caregivers — staggering numbers that are projected to triple by 2050. The dementia crisis is such a massive worldwide issue that the World Health Organization (WHO) announced a strategic public health action plan, including compiling an organized database of quality dementia research and creating guidelines for the prevention of dementia. The guidelines have just been published, a 96-page document that is summarized here, as well as in th...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Exercise and Fitness Healthy Aging Memory Nutrition Source Type: blogs
CONCLUSIONS: A large proportion of women experience several comorbidities, highlighting the need to address the chronic non-communicable disease epidemic in SA and to co-ordinate multidisciplinary primary-, secondary- and tertiary-level care in the country's complex healthcare system for better outcome. PMID: 31084693 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
This study, as well as the larger SPRINT study, also demonstrated that overall intensive treatment of blood pressure in older adults is safe. However, we do know that some individuals may develop dizziness, imbalance, and in rare instances strokes with intensive blood pressure lowering. For that reason, it is important to discuss your blood pressure management with your primary care physician and follow his or her recommendation. How do cardiovascular risk factors affect brain health? We have evidence from studies of the population, studies of brain scans, and studies of animals, that treatment of cardiovascular risk facto...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Heart Health Hypertension and Stroke Memory Prevention Source Type: blogs
In conclusion, the impaired in situ activity of RyR2 may also account for the poor overall cardiac outcome reported in MetS patients; hence, the SERCA pump and RyR2 are both attractive potential targets for future therapies. Introduction Metabolic syndrome (MetS) is a cluster of biochemical and physiological risk factors for cardiovascular disease and diabetes mellitus type 2 (DM2); it represents a severe public health problem around the world (Alberti et al., 2009). Risk factors for MetS include obesity (particularly central obesity), elevated triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Mildren Porchas-Quijada1, Zyanya Reyes-Castillo1*, José Francisco Muñoz-Valle2, Sergio Durán-Barragán3,4, Virginia Aguilera-Cervantes1, Antonio López-Espinoza1, Mónica Vázquez-Del Mercado4, Mónica Navarro-Meza1 and Patricia López-Uriarte1 1Instituto de Investigaciones en Comportamiento Alimentario y Nutrición, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán, Mexico 2Instituto de Investigaciones en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexic...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Dan Hu1†, Meijin Zhang2†, Hejun Zhang1, Yan Xia1, Jinxiu Lin2, Xiongwei Zheng1, Feng Peng2* and Wenquan Niu3* 1Department of Pathology, Fujian Cancer Hospital &Fujian Medical University Cancer Hospital, Fuzhou, China 2Department of Cardiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, China 3Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China Background and Objectives: Growing evidence indicates that metabolic syndrome confers a differential risk for the development and progression of many types of cancer, especially in the digestive tr...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Shafqat Ahmad1,2,3*, Syeda Sadia Fatima4, Gull Rukh5 and Caren E. Smith6 1Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden 2Preventive Medicine Division, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States 3Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States 4Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan 5Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden 6Nutrition and Genomics Laboratory, Jean Mayer U. S. Depa...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusions: Our results suggest Medicaid expansion benefited a population with unique needs, and that Medicaid expansion could be a valuable tool in addressing the opioid overdose epidemic.
Source: Medical Care - Category: Health Management Tags: Brief Reports Source Type: research
This study, called OMNI Heart (Optimal Macronutrient Intake to Prevent Heart Disease) examined 164 overweight and obese adults with prehypertension or Stage 1 hypertension, and replaced some of the carbohydrates in the DASH diet with either healthy protein (from fish, nuts, beans, and legumes) or unsaturated fats (from olive oil, nuts, avocado, and nut butters). Again calories were kept neutral to avoid weight gain or loss. Results showed that substituting healthy protein or healthy fats for some of the carbohydrate lowered LDL (bad) cholesterol, blood pressure, and triglycerides even further than the DASH diet alone. Putt...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diet and Weight Loss Health Healthy Eating Heart Health Source Type: blogs
da MA Abstract Overconsumption of a diet rich in fat and carbohydrates, called the Western diet, is a major contributor to the global epidemic of cardiovascular disease. Despite previously documented cardiovascular protection exhibited in female rats, this safeguard may be lost under certain metabolic stressors. We hypothesized that female Wistar rats challenged by a Western diet composed of 21% fat and 50% carbohydrate (34.1% sucrose) for 17 wk would develop endothelial dysfunction via endothelial Toll-like receptor 4 (TLR4) signaling. Western diet-fed female rats exhibited dysregulation of metabolism, revealing ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
More News: Cardiology | Cardiovascular | Cholesterol | Epidemics | Epidemiology | Heart | Hypertension | International Medicine & Public Health | Statin Therapy