Long-term Outcomes After Autologous or Tissue Expander/Implant Based Breast Reconstruction and Post-Mastectomy Radiation for Breast Cancer

Publication date: Available online 22 June 2019Source: Practical Radiation OncologyAuthor(s): Bindu V. Manyam, Chirag Shah, Neil M. Woody, Chandana A. Reddy, Michael A. Weller, Aditya Juloori, Mihir Naik, Stephanie Valente, Stephen Grobmyer, Paul Durand, Risal Djohan, Rahul D. TendulkarAbstractPurposeThe toxicity profile of breast reconstruction with post-mastectomy radiation therapy (PMRT) varies by technique and timing, and long-term data are limited. We compared rates of complications requiring re-operation (CRR) and reconstruction failure (RF) between immediate autologous reconstruction (I-AR), immediate tissue expander/implant reconstruction (I-TE/I), delayed AR (D-AR), and delayed TE/I (D-TE/I) in patients receiving PMRT.MethodsPatients who received AR or TE/I, and PMRT between 2000-2008 were included. Reconstruction was immediate if performed on same day as mastectomy, followed by PMRT (I-AR or I-TE/I) or delayed if following PMRT (D-AR and D-TE/I). CRR was defined as unplanned return to operating room due to infection, dehiscence, necrosis, hematoma, or hernia (with AR) and extrusion, leak, or contracture (with TE/I). RF was defined as unplanned conversion to another reconstruction technique or to flat chest wall. Cumulative incidence of CRR and RF was calculated using Kaplan Meier and compared using log-rank test. Logistic regression was used to identify variables associated with CRR and RF.Results204 patients were included. Median follow-up was 8 years. There were 1...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Women with breast cancer are often offered to undergo immediate or delayed breast reconstruction surgery (BRS). Reconstructed women with prosthesis may complain of chest pain related to the surgery or to other conditions including coronary ischemia. Many women have risk factors of coronary artery disease (CAD) including diabetes, hypertension and others as well as chemotherapy or radiotherapy, all increase the risk of CAD.1 To our knowledge no studies have examined the effect of BRS on the electrocardiogram (ECG) which is a major tool in the evaluation of chest pain or other cardiac symptoms.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
In conclusions, dairy may be part of a healthy diet; however, additional studies exploring confounding factors are needed to ascertain the potential detrimental effects. PMID: 31199182 [PubMed - as supplied by publisher]
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
AbstractCancer is the second leading cause of death in the USA, and cardiovascular disease is the second leading cause of morbidity and mortality among cancer survivors. Cancer survivors share common risk factors for cardiovascular disease with non-cancer patients. With improved survival, cancer patients become susceptible to treatment-related toxicity often involving the heart. The impact of concurrent malignancy on outcomes particularly among heart failure patients is an area of active research. We studied the trends in the prevalence of a concurrent diagnosis of breast, prostate, colorectal, and lung cancer among admiss...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Prevention is often called the best medicine — but research has shown that millions of Americans are not getting the preventive care they should to live long, healthy lives. Obstacles like inadequate access to care and financial barriers can keep people away from the doctor, but anxiety and feeling like care is unnecessary are also common deterrents. “There are a lot of things that every person could do to stay healthy, and this could help people to feel better, improve their quality of life and help them to live longer,” says Dr. Alex Krist, a professor of family medicine at Virginia Commonwealth Univer...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Longevity public health Source Type: news
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many stag...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion The elucidation of the function of circRNAs is an emerging field of science with a tremendous potential after previously being dismissed as RNA artifacts. They are ubiquitously expressed and thousands of members have already been identified. This fact only expands their potential to possibly enhance our knowledge to understand the difference between health and disease. Owing to their structure stability and their presence in exosomes circRNAs may also exert their function in an autocrine, paracrine and possible endocrine fashion. In addition, the fact that circRNAs are widely distributed in the cellular compart...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Gui-Jiang Wei1,2, Ming-Qing Yuan1, Li-He Jiang1, Yu-Lan Lu3, Chun-Hong Liu3, Hong-Cheng Luo3, Hua-Tuo Huang3, Zong-Quan Qi1* and Ye-Sheng Wei1,2* 1Department of Cell Biology, Medical College of Guangxi University, Nanning, China 2Department of Medical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, China 3Department of Medical Laboratory, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China miRNAs are small non-coding RNAs modulating gene expression, and variants in miRNA genes are involved in the pathogenesis of ischemic stroke (IS). However, the effect of mi...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions In this review, we analyzed mechanisms through which mitobolites, a distinct set of mitochondria-generated metabolites, can be released from mitochondria and then act as second messengers that contribute to cellular and organismal aging by regulating longevity-defining processes outside of mitochondria. Our analysis indicates that in eukaryotes across phyla, these second messengers of cellular aging exhibit the following common features: (1) they are produced in mitochondria in response to certain changes in the nutrient, stress, proliferation or age status of the cell; it remains unknown, however, what kind o...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge Attila Fintha1, Ákos Gasparics2, László Rosivall3 and Attila Sebe3,4* 12nd Department of Pathology, Semmelweis University, Budapest, Hungary 21st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary 3Department of Pathophysiology, International Nephrology Research and Training Center, Semmelweis University, Budapest, Hungary 4Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany Back in 1995, a landmark paper was published, which shaped the fi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human diseases. FI...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Diabetes | Endocrinology | Hypertension | Mastectomy | Radiation Therapy | Smokers | Toxicology