Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials

Primary postpartum haemorrhage (PPH) is a major cause of morbidity and the leading cause of direct maternal death worldwide,[1] with uterine atony accounting for approximately 70% of all cases.[2] Oxytocin is the most commonly used uterotonic in the developed world, with recent Cochrane reviews showing that it is effective at treating PPH.[3,4] However, failure of PPH prophylaxis with oxytocin, as shown by the need for a rescue uterotonic, has been demonstrated to be as high as 13% in women having an elective caesarean delivery (CD).

Source: International Journal of Obstetric Anesthesia - June 23, 2019 Category: Anesthesiology Authors: D.N. Onwochei, J. Van Ross, P.M. Singh, A. Salter, D.T. Monks Tags: Original Article Source Type: research