Exhaled nitric oxide as a marker of chlorine exposure in young asthmatic swimmers

Allergic asthma is a Type 2 (T2) inflammatory disease commonly presented in childhood. A complex interplay between genetic and environmental factors has been implicated in its pathogenesis.1 Environmental exposures seem to play an important role in the rising trend of the disease prevalence.1,2 There are several preventable environmental factors known to increase the risk of asthma in children such as damp and moldy housing or cigarette smoke.1,2,3
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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It's not clear which inhaled corticosteroids and delivery devices have the least adverse impact on growth in children with persistent asthma, a systematic review concludes.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news
Authors: Sullivan PW, Kavati A, Ghushchyan VH, Lanz MJ, Ortiz B, Maselli DJ, LeCocq J Abstract Objective: To estimate the health-related quality of life (HRQoL) and health utilities among asthma patients with and without comorbid allergies in a managed care population. Methods: This was a retrospective analysis of patient survey responses and pharmacy claims from the Observational Study of Asthma Control and Outcomes (OSACO). Patients ≥12 years-old with persistent asthma received four identical surveys between April-2011 and December-2012. The presence of allergy was identified by a positive response to a survey...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
AbstractPurpose of ReviewThis review aimed to introduce the regulations management and current situations of drug safety evaluation in China.Recent FindingsThe nationwide implementation of good laboratory practice and good clinical practice guarantees the quality of pre-marketing drug safety evaluation. In recent years, post-marketing drug safety monitoring is changing from passive mode to the combination of active and passive monitoring. A national adverse drug reaction monitoring sentinel alliance has been created to actively identify, report, and evaluate adverse reactions, with more than 1.4 million cases reported in 2...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
This study aims to evaluate public perceptions of need and benefit of providing local pollen information. Individuals aged 18  years and older were contacted through AusPollen Smartphone Apps (Brisbane, Sydney, Canberra and Melbourne), Australian Society for Clinical Immunology and Allergy, Asthma Australia and social media. A pilot questionnaire was developed in consultation with partner organisations, including select q uestions drawn from the National Young People and Asthma Survey. The questionnaire consisted of four sections: participant demographics, allergic rhinitis and asthma symptoms, symptom management and ...
Source: Aerobiologia - Category: Environmental Health Source Type: research
AbstractPurpose of ReviewCeliac disease (CD) is an autoimmune enteropathy triggered by gluten. The purpose of this review is to examine the major genetic and environmental factors that contribute to CD pathogenesis.Recent FindingsWe reviewed the current state of knowledge on the genetic and environmental components that play a role in CD onset. A genome-wide association study (GWAS) analysis has highlighted several genes other than HLA involved in CD. Recent studies have shown that HLA haplotype influences the microbiome composition in infants and that dysbiosis in the intestinal microflora, in turn, contributes to loss of...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
AbstractPurpose of the ReviewThis review aims at presenting the most significant data obtained in the field of the genetics of autoinflammatory disorders (AID) over the last past 5  years.Recent FindingsMore than 15 genes have been implicated in AID since 2014, unveiling new pathogenic pathways. Recent data have revealed atypical modes of transmission in several inherited AID, such as somatic mosaicism and digenism. First pieces of evidence showing an involvement of epigenetic modifications in the pathogenesis of AID have also been brought to light. Novel genetic data have been obtained on the molecular bases of genet...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Standardized house dust mite extract was more effective than non-standardized house dust extract for subcutaneous immunotherapy; however, the establishment of safer methods is warranted. PMID: 31308334 [PubMed - in process]
Source: Arerugi - Category: Allergy & Immunology Authors: Tags: Arerugi Source Type: research
Publication date: Available online 16 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Yoshihiko Raita, Carlos A. Camargo, Mohammad Kamal Faridi, David F.M Brown, Yuichi J. Shimada, Kohei HasegawaAbstructBACKGROUNDPatients with asthma have a high incidence of acute myocardial infarction and ischemic stroke.OBJECTIVEWe aim to investigate the acute effect of asthma exacerbation on these cardiovascular events.METHODSUsing population-based inpatient data of three geographically-diverse U.S. states (Florida, Nebraska, and New York) during 2011-2014, we conducted a self-controlled case serie...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 16 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Bryce C. Hoffman, Marissa Kuhl, Ronald Harbeck, Nathan Rabinovitch
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
(MediaSource) Many babies with eczema go on to develop food allergies, asthma and hay fever, and researchers at National Jewish Health say it's not a coincidence. The cracks caused by eczema weaken the skin barrier, allowing allergens to penetrate the skin and cause a sequence of allergic diseases, what experts call the 'atopic march.'
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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