Distinct Patterns of Neural Habituation and Generalization in Children and Adolescents With Autism With Low and High Sensory Overresponsivity

American Journal of Psychiatry, Ahead of Print.
Source: American Journal of Psychiatry - Category: Psychiatry Authors: Source Type: research

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Deficits in social interaction (SI) are a core symptom of autism spectrum disorders (ASDs); however, treatments for social deficits are notably lacking. Elucidating brain circuits and neuromodulatory signaling systems that regulate sociability could facilitate a deeper understanding of ASD pathophysiology and reveal novel treatments for ASDs. Here we found that in vivo optogenetic activation of the basolateral amygdala–nucleus accumbens (BLA-NAc) glutamatergic circuit reduced SI and increased social avoidance in mice. Furthermore, we found that 2-arachidonoylglycerol (2-AG) endocannabinoid signaling reduced BLA-NAc g...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The Eagles Autism Foundation will support 16 autism-related initiatives from the $3.6 million raised by participants in the second annual Eagles Autism Challenge last May. The winners encompass eight pilot studies, six community projects and two postdoctoral fellowships. The foundation received 52 research proposals for grant funding along with 17 community grant applications. Finalists for grant funding went through a detailed evaluation process conducted by an independent team of scientists…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Researchers at Flinders University in Australia have developed a handheld eye scanner that could help to identify children with autism spectrum disorder. The device allows clinicians to obtain light-adapted electroretinograms, which involves detectin...
Source: Medgadget - Category: Medical Devices Authors: Tags: Ophthalmology Pediatrics Psychiatry Source Type: blogs
DiscussionIf efficacy of the manualised A-FFIP early intervention is established, the current study has the potential to change clinical practice strongly towards the implementation of a low-intensity, evidence-based, natural early intervention in ASD. Early intervention in ASD requires specialist training, which subsequently needs to be developed or included into current training curricula.Trial registrationGerman Registry for Clinical Trials (Deutscher Register Klinischer Studien, DRKS); ID: 00016330. Retrospectively registered on 4 January 2019. URL:https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00016330.
Source: Trials - Category: Research Source Type: clinical trials
Conclusions and implicationsSensory Sensitivity Scales (SeSS) can be used to screen sensory sensitivity variability or identify and follow up the outcome of sensory interventions in adults.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Juliana Fetherman was in middle school when she started to notice that her younger brother, Michael, who has ADHD and autism, was having problems making friends.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
AbstractWe aimed at identifying early non-social behavioural indicators that predict later ASD. Likewise, we were interested in the moment in which non-social signs discriminate between children at elevated likelihood for ASD with a later diagnosis of ASD, and children at elevated likelihood for ASD with a typical developmental outcome. In addition, we intended to explore the developmental evolution of children ’s symptomatology over time. A systematic literature search was conducted for longitudinal studies on early non-social behavioural indicators among siblings at elevated likelihood for ASD. The following databa...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
ConclusionsContrary to prior reports, this large-scale study does not support the assumption that altered social brain activation during mentalizing forms a common neural marker of ASD, at least with the paradigm we employed. Yet, autistic individuals show socio-behavioral deficits. Our work therefore highlights the need to interrogate social brain function with other brain measures, such as connectivity and network-based approaches, using other paradigms, or applying complementary analysis approaches to assess individual differences in this heterogeneous condition.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Publication date: Available online 21 February 2020Source: Molecular Genetics and MetabolismAuthor(s): Gabriella A. Horvath, Robert M. Stowe, Carlos R. Ferreira, Nenad BlauAbstractPsychiatric symptoms are common manifestations in many inborn errors of metabolism (IEMs), ranging from attention deficit, anxiety and mood and behavioral disorders to psychosis. Furthermore, IEMs represent a significant percentage of all autism cases. We reviewed and updated the list of metabolic disorders known to be associated with various psychiatric manifestations and found more than 100 relevant IEMs. This represents the third of a series o...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Publication date: June 2020Source: Meta Gene, Volume 24Author(s): Fatemeh Beiranvandi, Mansoureh Akouchekian, Gholam Reza Javadi, Hossein DarvishAbstractAutism spectrum disorder (ASD) is a highly heritable neurodevelopment disease characterized by impaired social interactions, communication deficits, restricted interests, stereotyped and repetitive behaviors, which results from the interaction between genetic vulnerability and environmental factors. Our study was aimed to explore the association between CNTNAP2 gene polymorphism (rs2710102 C/T) and ENGRAILED-2 (EN2) (rs1861972 A/G) with the risk of autism in the Iranian po...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
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