Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: a comparison with lithium

Publication date: Available online 22 June 2019Source: Neuroscience LettersAuthor(s): Nastaran Rahimi, Mahsa Hassanipour, Fatemeh Yarmohammadi, Hedyeh Faghir-Ghanesefat, Nastaran Pourshadi, Erfan Bahramnejad, Ahmadreza DehpourAbstractThe neuro-protective effects of rubidium and lithium as alkali metals have been reported for different central nervous system dysfunctions including mania and depression. The aim of this study was evaluating as well as comparing the effects of rubidium chloride (RbCl) and lithium chloride (LiCl) on different seizures paradigms in mice and determining the involvement of NMDA receptors and nitrergic pathway.To assess the seizures threshold, animals received intravenous pentylenetetrazole (PTZ, 0.5%; 1 mL/min). Male NMRI mice (6-8 weeks) received intraperitoneal (i.p.) injections of different doses of RbCl and LiCl. Doses greater than 10 mg/kg of RbCl showed a significant anticonvulsant activity 60 minutes after administration; the anticonvulsant effects of LiCl was observed at the doses more than 5 mg/kg and after 30 minutes in PTZ-induced seizure threshold. But, RbCl (10, 20 mg/kg, i.p) or LiCl (5, 10 mg/kg, i.p) injection did not induce protection against maximal electroshock (MES) or intraperitoneal injection of PTZ lethal dose (80 mg/kg)-induced seizure models.Pre-treatment with L-NAME (non-selective nitric oxide synthase (NOS) inhibitor, 10 mg/kg; i.p.) and 7-nitroindazole (selective neuronal NOS inhibitor, 30 mg/kg; i.p.) ...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research