Viruses, Vol. 11, Pages 505: Peroxisome Proliferator-Activated Receptor Gamma (PPAR γ) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection

We examined the effect of rosiglitazone treatment during influenza and secondary bacterial (Methicillin resistant Staphylococcus aureus) pneumonia in mice. We found decreased influenza viral burden, decreased numbers of neutrophils and macrophages in bronchoalveolar lavage, and decreased production of cytokines and chemokines in influenza infected, rosiglitazone-treated mice when compared to controls. However, rosiglitazone treatment compromised bacterial clearance during influenza-bacterial super-infection. Both human and mouse data suggest that rosiglitazone treatment worsens the outcome of influenza-associated pneumonia.

Source: Viruses - May 31, 2019 Category: Virology Authors: Radha Gopal Angelico Mendy Michael A. Marinelli Lacee J. Richwalls Philip J. Seger Shivani Patel Kevin J. McHugh Helen E. Rich Jennifer A. Grousd Erick Forno John F. Alcorn Tags: Article Source Type: research