A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation
Condition: Transplanted Organ Rejection Intervention: Biological: FCR001 Sponsor: Talaris Therapeutics Inc. Not yet recruiting
We report here a huge ADPKD case of kidney transplantation concomitant with simple nephrectomy through thoracoabdominal approach that allows surgeons to manipulate the renal vessels, the adrenal grand, the trigonal ligament, and the lower pole of the kidney under the wide operative field. Because of the direct recognition of the surgical anatomy, it might be safe and feasible for simple nephrectomy in huge ADPKD patients undergoing concomitant kidney transplantation despite of the wide skin incision required by this approach.
We have read the letter by Lenain et al.,1 which raised concerns about the potential for collinearity given our use of the kidney donor profile index (KDPI) for multivariable adjustment in analyses that showed deceased-donor acute kidney injury (AKI) was not independently associated with allograft failure at a median follow-up of 4 y ears.2 We used KDPI for adjustment because the score is very familiar to the transplant community for describing overall organ quality given that it incorporates 10 donor factors associated with allograft survival.
A 55-year-old man with a history of end-stage renal disease due to autosomal dominant polycystic kidney disease and bilateral nephrectomy without adrenalectomy underwent his first kidney transplantation after 6 years of hemodialysis. The patient had no history of donor-specific antibodies. The donor was described as a 69-year-old man with a history of active smoking and aortic valvulopathy who died of a stroke without cardiac arrest or collapse. Maintenance immunosuppressive therapy consisted of low-dose tacrolimus and everolimus.
A 30-year-old man who underwent renal transplantation 10 years ago presented with multiple painful swellings in his limbs and joints with limitation of movement (Supplementary Figure S1), which had developed over 3 weeks. He was on dual immunosuppression with prednisolone and tacrolimus because of multiple infections in the past. He was normotensive and afebrile. Each swollen area was tender and fluctuant. His hemoglobin level was 7.3 g/dl; the total leukocyte count was 21,800 cells/mm3; and the serum creatinine level was 2.9 mg/dl.
CONCLUSIONS Peritoneal dialysis is not a risk factor for postoperative complications after SPKT. PMID: 31320604 [PubMed - in process]
Vitamin D in kidney transplant recipients . Clin Nephrol. 2019 Jul 19;: Authors: Battaglia Y, Cojocaru E, Fiorini F, Granata A, Esposito P, Russo L, Bortoluzzi A, Storari A, Russo D Abstract Kidney transplant recipients (KTRs) are susceptible to low levels of vitamin D, which may be responsible for mineral and bone metabolism disorders and play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic, and infectious complications after kidney transplant. Kidney Disease Improving Global Outcomes (KDIGO) guidelines of the year 2017 recommended vitamin D supplementation in the ...
BACKGROUND: Dialysis is the first procedure to partially replace renal function in end-stage renal diseases, despite several adverse side effects, such as infections. The primary aim of this study was to evaluate the levels of immune CMV-specific CD8+ T cells in a representative cohort of pre-transplant patients receiving hemodialysis (HD) or peritoneal dialysis (PD). The secondary aim was to monitor the CMV-specific CD8+ T cells in kidney transplant recipients undergoing different types of dialysis during the first year following their transplant. METHODS: 69 patients were enrolled and examined with respect to the type o...
Notice of proposed rule from the Centers for Medicare and Medicaid Services to implement two new mandatory Medicare payment models. The End-Stage Renal Disease (ESRD) Treatment Choices Model (ETC Model) is a mandatory payment model to encourage greater use of home dialysis and kidney transplants. The Radiation Oncology Model (RO Model) promotes quality and financial accountability for providers and suppliers of radiotherapy and tests whether making prospective episode payments to hospital outpatient departments and freestanding radiation therapy centers improves quality of care and reduces Medicare spending. Comments on th...
Stevie Wonder will receive a kidney transplant in the coming months. Kidney disease is surprisingly common, especially in minority populations. Kidney donation can be performed from a living donor, and can be scheduled as opposed to performed as an emergency surgery.
Conclusion: Our study showed that bendamustine is a potentially toxic agent in the conditioning regimen for autologous SCT, resulting in significant liver, kidney, and gastrointestinal toxicity. Further studies are required to assess its safety and efficacy at reduced doses. PMID: 31309088 [PubMed]