A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component

Conclusion GX showed promising efficacy in patients with SRCC. GX could be considered as a treatment option for patients with SRCC and should be confirmed in larger clinical trials.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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ConclusionPositron emission computed tomography is useful for the diagnosis of head and neck squamous cell carcinoma, improving the patient's staging especially when detecting cervical and distant metastases. Therefore, we consider that the use of positron emission computed tomography for the staging of patients with head and neck squamous cell carcinoma is a diagnostic test to be considered.ResumoIntroduçãoO carcinoma espinocelular de cabeça e pescoço é o sétimo tumor maligno mais comum. Os avanços no tratamento melhoraram as taxas de sobrevida global nos últimos ano...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 20 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Do Jung Kim, Sak Lee, Hyun-Chel Joo, Heirim Lee, Bumhee Park, Young-Nam Youn, Kyung-Jong Yoo, Seung Hyun LeeAbstractBackgroundLong-term outcomes of mitral valve replacement (MVR) recipients with pulmonary hypertension (PH) remain unclear. We determined the effect of concomitant PH on the clinical outcomes and late-onset progression of tricuspid regurgitation (TR) following MVR for rheumatic mitral stenosis.MethodsWe retrospectively reviewed 394 patients who underwent MVR between January 2000 and December 2013. PH was defined as ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSIONS Parthenolide inhibited the growth and migration of MDA-T32 human papillary thyroid carcinoma cells in vitro and mouse tumor xenografts and activated autophagy and apoptosis by downregulation of the mTOR/PI3K/AKT signaling pathway. PMID: 31322140 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Gabriel J Starrett, Christopher B BuckIn 2014, the International Agency for Research on Cancer judged Merkel cell polyomavirus (MCPyV) to be a probable human carcinogen. BK polyomavirus (BKPyV, a distant cousin of MCPyV) was ruled a possible carcinogen. In this review, we argue that it has recently become reasonable to view both of these viruses as known human carcinogens. In particular, several complementary lines of evidence support a causal role for BKPyV in the development of bladder carcinomas affecting organ transplant patients. T...
Source: Current Opinion in Virology - Category: Virology Source Type: research
In this study, we characterized the clinical features of SFTS in cats and their associated risk factors, by evaluating the clinical parameters retrospectively. A phylogenetic analysis on SFTSV was also conducted. There were no obvious tendencies in age or sex, outdoor cats were commonly at risk of SFTSV infection. All infected cats showed acute onset of clinical signs including anorexia and lethargy, while 68.2% of the cats showed fever and 41.7% showed vomiting. The case fatality rate was 62.5%. Thrombocytopenia, leukopenia, and elevated serum total bilirubin, serum amyloid A, and creatinine phosphokinase concentration we...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 20 July 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Carolina Villadóniga, Ana María B. CanteraAbstractAngiotensin converting enzyme (ACE) plays a key role in regulating blood pressure and ACE inhibitors are first-line drugs for treating hypertension. Food protein-derived peptides with ACE inhibitory activity are natural and safe alternatives for both prevention and treatment of hypertension. The second most abundant whey protein, α-lactalbumin (ALA) was hydrolysed with proteases from Bromelia antiacantha Bertol., a native plant. Two new peptides w...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
CONCLUSIONSRYGB offers sustained, long-term weight loss with significant resolution of major comorbidities in older veterans, with acceptably low morbidity and mortality.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: August 2019Source: European Journal of Surgical Oncology, Volume 45, Issue 8Author(s): Georg Lurje, Jan Bednarsch, Zoltan Czigany, Isabella Lurje, Ivana Katharina Schlebusch, Joerg Boecker, Franziska Alexandra Meister, Frank Tacke, Christoph Roderburg, Marcel Den Dulk, Nadine Therese Gaisa, Philipp Bruners, Ulf Peter NeumannAbstractIntroductionCholangiocellular carcinoma (CCA) is an aggressive malignancy with a dismal prognosis. Among curative treatment options for CCA, radical surgical resection with extrahepatic bile duct resection, hepatectomy and en-bloc lymphadenectomy are considered the mainstay of ...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
This study aims to compare the efficacy and safety of treatment after transarterial chemoembolization(TACE) with best supportive care (BSC) in patients with hepatocellular carcinoma (HCC) with PVTT.MethodsThis retrospective study was conducted on 1,040 patients with HCC with PVTT who were treated either with TACE (n = 675) or BSC (n = 365). BSC did not include sorafenib. The two groups of patients were compared with or without propensity score matching. A subgroup analysis was subsequently performed by stratifying patients according to the stages of PVTT in the Cheng's PVTT classification.ResultsIn PVTTtypes I-III,...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 21 July 2019Source: Respiratory Medicine Case ReportsAuthor(s): Meghan M. Cirulis, Lynda O. Jorgensen, Ronald W. DayAbstractThe pulmonary arterial pressure of a child with severe pulmonary arterial hypertension immediately normalized while breathing nitric oxide during heart catheterization at 8 years of age. Her acute pulmonary vascular response to nitric oxide has persisted throughout her life. Her acute response to other medications has been similar to her long-term response to medications in the same class. Acute vasodilator testing with inhaled nitric oxide and other medications may ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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