Chasing Uptake: Super-Resolution Microscopy in Endocytosis and Phagocytosis.

Chasing Uptake: Super-Resolution Microscopy in Endocytosis and Phagocytosis. Trends Cell Biol. 2019 Jun 18;: Authors: Baranov MV, Olea RA, van den Bogaart G Abstract Since their invention about two decades ago, super-resolution microscopes have become a method of choice in cell biology. Owing to a spatial resolution below 50 nm, smaller than the size of most organelles, and an order of magnitude better than the diffraction limit of conventional light microscopes, super-resolution microscopy is a powerful technique for resolving intracellular trafficking. In this review we discuss discoveries in endocytosis and phagocytosis that have been made possible by super-resolution microscopy - from uptake at the plasma membrane, endocytic coat formation, and cytoskeletal rearrangements to endosomal maturation. The detailed visualization of the diverse molecular assemblies that mediate endocytic uptake will provide a better understanding of how cells ingest extracellular material. PMID: 31227311 [PubMed - as supplied by publisher]
Source: Trends in Cell Biology - Category: Cytology Authors: Tags: Trends Cell Biol Source Type: research