Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy.

Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy. Curr Opin Microbiol. 2019 Jun 18;51:46-50 Authors: Segall AM, Roach DR, Strathdee SA Abstract Increasingly, clinical infections are becoming recalcitrant or completely resistant to antibiotics treatment and multidrug resistance is rising alarmingly. Patients suffering from infections that used to be treated successfully by antibiotic regimens are running out of the treatment options. Bacteriophage (phage) therapy, long practiced in parts of Eastern Europe and the states of the former Soviet Union, is now being reevaluated as a treatment option complementary to and synergistic with antibiotic treatments. We discuss some current studies that have addressed synergistic killing activity between phages and antibiotics, the issues of treatment order and antibiotic class, and point to considerations that will have to be addressed by future studies. Overall, co-treatments with phages and antibiotics promise to extend the utility of antibiotics in current use. Nevertheless, a lot of work, both basic and clinical, remains to be done before such co-treatments become routine options in the hospital setting. PMID: 31226502 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research

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Publication date: Available online 27 January 2020Source: International Journal of PharmaceuticsAuthor(s): Lokesh Kaushik, Shubham Srivastava, Anshul Panjeta, Dasharath Chaudhari, Rohan Ghadi, Kaushik Kuche, Ruchi Malik, Simran Preet, Sanyog Jain, Kaisar RazaAbstractDocetaxel (DTX), a widely prescribed anticancer agent, is now associated with increased instances of multidrug resistance. Also, being a problematic BCS class IV drug, it poses challenges for the formulators. Henceforth, it was envisioned to synthesize an analogue of DTX with a biocompatible lipid, i.e., palmitic acid. The in-silico studies (molecular docking a...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
In this study, rociletinib (CO-1686), a mutant-selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), was found to significantly improve the efficacy of ABCG2 substrate chemotherapeutic agents in the transporter-overexpressing cancer cells in vitro and in MDR tumor xenografts in nude mice, without incurring additional toxicity. Mechanistic studies revealed that in ABCG2-overexpressing cancer cells, rociletinib inhibited ABCG2-mediated drug efflux and increased intracellular accumulation of ABCG2 probe substrates. Moreover, rociletinib, inhibited the ATPase activity, and competed with [125I] iodo...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
ConclusionWidespread dissemination ofE. coli strains carryingmcr-1 encoding resistance to colistin in the present study is alarming as this is the last resort drug for the treatment of infections caused by MDR gram-negative bacteria resistant to almost all drugs used commonly.
Source: Gut Pathogens - Category: Microbiology Source Type: research
This study points to the potential of amyloidosis inhibition with nanomaterials as a safe and facile antimicrobial strategy. AbstractMultidrug resistance of bacteria is a major challenge due to the wide ‐spread use of antibiotics. While a range of strategies have been developed in recent years, suppression of bacterial activity and virulence via their network of extracellular amyloid has rarely been explored, especially with nanomaterials. Here, silver nanoparticles and nanoclusters (AgNPs and Ag NCs) capped with cationic branched polyethylenimine polymer are synthesized, and their antimicrobial potentials are determined...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
This study presents a combined dielectrophoresis (DEP) - Raman Spectroscopy (RS) method to obtain direct, real-time measurements of the susceptibility of a suspension of planktonic bacteria without labelling or other time-consuming and intrusive sample preparation processes. Using an in-house constructed DEP-Raman device, we demonstrated the susceptibility of Escherichia coli MG1655 towards the second-generation fluoroquinolone antibiotic ciprofloxacin (CP) after only 1 h of treatment, by monitoring spectral changes in the chemical fingerprint of bacteria related to the mode of action of the drug. Spectral variance ...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ06173H, PaperMuHan Zhao, Jian-Bin Zhen, Ke-Wu Yang, Ya Liu, Jia-Qi Li, Suqing Shi The overuse of traditional antibiotics has resulted in a large number of bacteria that are resistant to the antibiotics, therefore, the development of new antibacterial agents is imminent to combat... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Molecules, Vol. 25, Pages 537: Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives—An In Vitro Study Molecules doi: 10.3390/molecules25030537 Authors: Michalak Lach Antoszczak Huczyński Suchorska Polyether ionophore salinomycin (SAL) and its semi-synthetic derivatives are recognized as very promising anticancer drug candidates due to their activity against various types of cancer cells, including multidrug-resistant populations. Ovarian cancer is the deadliest among gynecologic malignancies, which is connected with the development of chemoresistant ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 23 January 2020Source: Pharmacological ResearchAuthor(s): Su-Wei Xu, Betty Yuen Kwan Law, Steven Li Qun Qu, Sami Hamdoun, Juan Chen, Wei Zhang, Jian-Ru Guo, An-Guo Wu, Simon Wing Fai Mok, David Wei Zhang, Chenglai Xia, Yoshikazu Sugimoto, Thomas Efferth, Liang Liu, Vincent Kam Wai WongAbstractMultidrug resistance (MDR) represents an obstacle in anti-cancer therapy. MDR is caused by multiple mechanisms, involving ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp), which reduces intracellular drug levels to sub-therapeutic concentrations. Therefore, sensitizing agents ret...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsThis developed population pharmacokinetic model can be used to calculate cycloserine concentrations and exposure in patients with multidrug-/extensively drug-resistant tuberculosis. This model was successfully validated by internal and external validation methods. This study showed that the AUC0 –24 h of cycloserine can be estimated in patients with multidrug-/extensively drug-resistant tuberculosis using a 1- or 2-point limited sampling strategy in combination with the developed population pharmacokinetic model. This strategy can be used in studies to correlate drug exposure with clinical outcome. Th...
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Condition:   Tuberculosis, Multidrug-Resistant Intervention:   Diagnostic Test: targeted Next Generation Sequencing (tNGS) Sponsor:   Foundation for Innovative New Diagnostics, Switzerland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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