The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly.

The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly. Matrix Biol. 2019 Jun 18;: Authors: Godwin ARF, Singh M, Lockhart-Cairns MP, Alanazi Y, Cain SA, Baldock C Abstract Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form beaded microfibrils which are essential components of most extracellular matrices. Fibrillin microfibrils have specific biomechanical properties to endow animal tissues with limited elasticity, a fundamental feature of the durable function of large blood vessels, skin and lungs. They also form a template for elastin deposition and provide a platform for microfibril-elastin binding proteins to interact in elastic fibre assembly. In addition to their structural role, fibrillin microfibrils mediate cell signalling via integrin and syndecan receptors, and microfibrils sequester transforming growth factor (TGF)β family growth factors within the matrix to provide a tissue store which is critical for homeostasis and remodelling. PMID: 31226403 [PubMed - as supplied by publisher]
Source: Matrix Biology - Category: Molecular Biology Authors: Tags: Matrix Biol Source Type: research